UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer

Oncology Letters
Ge Ge GuanYun Feng Zhou

Abstract

Human telomerase reverse transcriptase (hTERT) is a critical factor in unlimited cell proliferation and immortalization, with numerous studies demonstrating that high expression of hTERT is a poor prognostic factor in various types of cancer. Ubiquitin-conjugating enzyme E2D 3 (UBE2D3) is a member of the E2 family, and participates in the ubiquitin proteasome pathway to regulate basic cellular activities, such as cell cycle control, the DNA damage response, apoptosis, and tumorigenesis. Our previous study initially determined that downregulation of UBE2D3 expression increases hTERT expression and cell proliferation, however, the association between the expression of these two proteins and their functions in cancer tissues remains unknown. Therefore, the protein expression levels of hTERT and UBE2D3 were evaluated in 150 esophageal cancer and 30 adjacent healthy tissue samples by performing immunohistochemical analysis. Concurrently, the clinicopathological data of the enrolled patients were obtained to allow correlation analysis. It was identified that the expression of hTERT in the esophageal cancer tissues was significantly higher compared with that of the adjacent tissues (P=0.015), however, the expression of UBE2D3 was sign...Continue Reading

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Citations

Feb 15, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Mitzi García-OlivaresDavid Barrera
Apr 4, 2021·International Journal of Molecular Sciences·Xiaodi DuGuangyou Yang

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Methods Mentioned

BETA
two-hybrid
dissection
light microscopy
ubiquitination

Software Mentioned

SPSS

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