Ubiquitin conjugate dynamics in the gut and liver of hibernating ground squirrels

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Frank van Breukelen, V Carey

Abstract

Protein synthesis is severely depressed in hibernating mammals. In the absence of significant protein synthesis, the continued turnover of proteins as a function of normal cellular activity would result in the net depletion of protein pools. We measured levels of ubiquitylated proteins in the gut of thirteen-lined ground squirrels ( Spermophilus tridecemlineatus) and liver of golden-mantled ground squirrels ( Spermophilus lateralis). In both tissues, ubiquitin conjugate concentrations increased during entrance into torpor and were elevated 2-3 fold by late torpor compared with levels in active animals. The data are consistent with a depression of proteolysis with a resultant high level of ubiquitylated proteins during the natural hypothermia of torpor. The periodic returns to euthermy during the hibernation season allow for degradation of these conjugated proteins and may serve to restore protein pools.

Citations

Aug 22, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Anne E TodghamGretchen E Hofmann
Aug 13, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Megan M NowellBryan C Rourke
Feb 4, 2010·Apoptosis : an International Journal on Programmed Cell Death·Frank van BreukelenJason E Podrabsky
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joan Smith SonnebornPaul Thomas
Dec 18, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Camie L MellerJason E Podrabsky
Nov 12, 2013·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Pierre J LyonsPier Morin
May 25, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Vanja VelickovskaFrank van Breukelen
Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Beau D ReillyCraig E Franklin
Aug 24, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Clark J NelsonHannah V Carey
Jun 19, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·James F Staples, Leslie T Buck
Mar 10, 2004·Biological Reviews of the Cambridge Philosophical Society·Kenneth B Storey, Janet M Storey
Feb 8, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Peter R OeltgenDonald B Witzke
Jul 22, 2004·Molecular & Cellular Proteomics : MCP·L Elaine EppersonSandra L Martin
Jan 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas Ruf, Walter Arnold
Apr 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sandra L MartinHannah V Carey
Dec 25, 2008·Physiological Genomics·Clark J NelsonHannah V Carey
May 3, 2015·Physiology·Walter ArnoldThomas Ruf
May 22, 2016·Physiological Genomics·Scott T CooperMarshall Hampton
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved