Ubiquitin-conjugating enzyme E2C: a potential cancer biomarker

The International Journal of Biochemistry & Cell Biology
Chanlu XieQihan Dong

Abstract

The ubiquitin-conjugating enzymes 2C (UBE2C) is an integral component of the ubiquitin proteasome system. UBE2C consists of a conserved core domain containing the catalytic Cys residue and an N-terminal extension. The core domain is required for ubiquitin adduct formation by interacting with the ubiquitin-fold domain in the E1 enzyme, and contributes to the E3 enzyme binding. UBE2C N-terminal extension regulates E3 enzyme activity as a part of an intrinsic inhibitory mechanism. UBE2C is required for the destruction of mitotic cyclins and securin, which are essential for spindle assembly checkpoint and mitotic exit. The UBE2C mRNA and/or protein levels are aberrantly increased in many cancer types with poor clinical outcomes. Accumulation of UBE2C stimulates cell proliferation and anchorage-independent growth. UBE2C transgenic mice are prone to develop spontaneous tumors and carcinogen-induced tumor with evidence of chromosome aneuploidy.

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·A AristarkhovJ V Ruderman
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M TownsleyJ V Ruderman
Apr 3, 2002·The Journal of Biological Chemistry·Yaqiong LinRavi Basavappa
Jul 27, 2004·Protein Science : a Publication of the Protein Society·Nobukazu NamekiShigeyuki Yokoyama
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Robert GrützmannHans Detlev Saeger
Oct 24, 2009·Nature Reviews. Molecular Cell Biology·Yihong Ye, Michael Rape
Dec 17, 2009·The Journal of Biological Chemistry·Minglian ZhaoChang-Wei Liu
Jan 13, 2010·The Journal of Cell Biology·Janine H van ReeJan M van Deursen
Apr 2, 2011·The Journal of Biological Chemistry·Somsubhra NathSusanta Roychoudhury
Apr 12, 2011·Seminars in Cell & Developmental Biology·Hermann-Josef Meyer, Michael Rape
Dec 16, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhonglin HaoJohn Cowell
Jul 24, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Alexandre VasiljevicMichelle Fèvre-Montange
Feb 19, 2013·Molecular Cell·Shaun K Olsen, Christopher D Lima
Jun 19, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Jing LuGuangwei Wei

❮ Previous
Next ❯

Citations

Mar 5, 2015·International Journal of Molecular Sciences·Cheng WangLi-Ming Zhao
Apr 29, 2015·Molecular Carcinogenesis·Nunzio Antonio CacciolaPierlorenzo Pallante
Aug 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Akter Khondker AyeshaTakeshi Senga
Aug 29, 2018·Protein Science : a Publication of the Protein Society·Kazuhide MiyamotoKazuki Saito
May 10, 2019·International Journal of Molecular Sciences·Hassan DastsoozSalvatore Oliviero
May 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guangping YuShengsong Tang
Nov 21, 2018·Journal of Ovarian Research·Wenyu LiFen Fu
Nov 28, 2019·Molecular and Cellular Biochemistry·Aymen ShatnawiEfrosini Tsouko
Jun 8, 2019·Molecular Medicine Reports·Peng HaoFeihong Ma
Jun 20, 2020·Protein Science : a Publication of the Protein Society·Kazuhide MiyamotoKazuki Saito
Apr 4, 2021·International Journal of Molecular Sciences·Xiaodi DuGuangyou Yang
Oct 9, 2021·Chinese Medical Journal·Zi-Nan LuGang Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.