Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury

Kidney International
Hirotaka FukasawaAkira Hishida

Abstract

Transforming growth factor-beta (TGF-beta) plays a critical role in the progression of renal fibrosis. The activity of TGF-beta is tightly controlled by various mechanisms, among which antagonizing Smad-mediated gene transcription by co-repressors represents one of the important components. We investigated the expression, degradation, and ubiquitination of Smad transcriptional co-repressors SnoN (ski-related novel gene N) and Ski (Sloan-Kettering Institute proto-oncogene) in renal fibrogenesis. We also studied the involvement of Smad-ubiquitination regulatory factor 2 (Smurf2) in ubiquitination of SnoN protein. The kidneys of mice with unilateral ureteral obstruction (UUO) and those of sham-operated mice were used. Renal lesions and the expression of TGF-beta1, type I collagen, SnoN, Ski, and Smurf2 were examined by immunohistochemistry, Western blot, and/or real-time reverse transcriptase-polymerase chain reaction. Degradation and ubiquitination of SnoN/Ski proteins were also investigated. The obstructed kidneys of UUO mice showed progressive tubulointerstitial fibrosis, high expression levels of TGF-beta1, type I collagen, SnoN and Ski mRNAs, and low levels of SnoN and Ski proteins. Both degradation and ubiquitination of SnoN...Continue Reading

References

Dec 1, 1992·The Journal of Cell Biology·M B Sporn, A B Roberts
Jul 25, 1989·Nucleic Acids Research·N NomuraR Ishizaki
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Dec 1, 1996·Journal of the American Society of Nephrology : JASN·A A Eddy
Jul 15, 1997·Nucleic Acids Research·S Pearson-White, R Crittenden
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y SunR A Weinberg
Feb 5, 2000·Cell·J L Wrana
May 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A CiechanoverA L Schwartz
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangR Derynck
Apr 20, 2001·Cytokine & Growth Factor Reviews·X LiuH F Lodish
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Saulo Klahr, Jeremiah Morrissey
Oct 11, 2002·The Journal of Pathology·Takuya WatanabeAkira Hishida
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Minoru FukuchiHiroyuki Kuwano
Jan 15, 2004·The Journal of Clinical Investigation·Yoshihide AsanoKunihiko Tamaki
Apr 28, 2004·Current Opinion in Genetics & Development·Kunxin Luo
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hirotaka FukasawaAkira Hishida
May 3, 2005·FEBS Letters·Naro OhashiMasatoshi Kitagawa

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Citations

Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Sayuri SuzukiMasatoshi Kitagawa
Dec 31, 2008·Cell Research·Julien Deheuninck, Kunxin Luo
May 29, 2009·Nature Reviews. Nephrology·María T Grande, José M López-Novoa
Feb 1, 2011·Clinical and Experimental Pharmacology & Physiology·Peter Boor, Jürgen Floege
Mar 21, 2008·American Journal of Physiology. Renal Physiology·Ruoyun TanYouhua Liu
Jan 21, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Jun 12, 2012·Clinical and Experimental Nephrology·Hirotaka Fukasawa
May 12, 2006·Kidney International·Y HuangN A Noble
Sep 17, 2011·Burns : Journal of the International Society for Burn Injuries·Zhi ZhangDavid N Herndon
Jul 16, 2011·Cytokine & Growth Factor Reviews·Claire E Hills, Paul E Squires
Sep 8, 2010·Seminars in Cell & Developmental Biology·Elena Vasyutina, Mathias Treier
Aug 7, 2007·The American Journal of Pathology·Bärbel Lange-SperandioFranz Schaefer
Oct 24, 2006·Chinese Journal of Digestive Diseases·Yu CaiJi Yao Wang
Nov 6, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Abril Martínez-RizoJuan Armendáriz-Borunda
May 19, 2017·Journal of Cellular Biochemistry·Reyhaneh RabieianHamed Mirzaei
Apr 14, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiao-Zhao LiHua-Ping Nie
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Ruoyun TanYouhua Liu
Mar 14, 2008·American Journal of Physiology. Renal Physiology·Gerard ElbergMartin A Turman
Nov 9, 2012·Annals of Biomedical Engineering·Nicholas A VavalleF Scott Gayzik
Sep 13, 2013·The Journal of Toxicological Sciences·Masafumi TomitaOsamu Miyamoto
Nov 9, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Matthew R ZeglinskiIan M C Dixon
Aug 5, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masayoshi IizukaTomoki Okazaki
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaqi TangPaul J Higgins
Jun 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rohan SamarakoonPaul J Higgins
Apr 28, 2017·Molecular Medicine Reports·Zhuojia XuWenhu Liu
Jun 13, 2018·Signal Transduction and Targeted Therapy·Angeles C Tecalco-CruzMarina Macías-Silva
Aug 15, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gui-Fang SunDian-Xu Feng
Jan 23, 2021·Journal of Cell Communication and Signaling·René Fernando Abarca-BuisEdgar Krötzsch
Jan 14, 2021·Burns : Journal of the International Society for Burn Injuries·Zhi ZhangXiaojian Li
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin ChenYing-Yong Zhao

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