Ubiquitin-Dependent Regulation of Stem Cell Biology

Trends in Cell Biology
Achim WernerMichael Rape

Abstract

The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program. To guide their decisions, stem cells make frequent use of ubiquitylation, a post-translational modification that can affect the activity, interaction landscape, or stability of stem cell proteins. In this review we discuss novel findings that have provided insight into ubiquitin-dependent mechanisms of stem cell control and revealed how an essential and highly conserved protein modification can shape metazoan development.

Citations

Mar 8, 2018·Scientific Reports·Isabel SaezDavid Vilchez
Mar 7, 2018·G3 : Genes - Genomes - Genetics·James L LissemoreEleanor M Maine
May 6, 2019·International Journal of Molecular Sciences·Karamat MohammadVladimir I Titorenko
May 14, 2019·Journal of Cellular Biochemistry·Wenjun HuangRong Li
Jan 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maud de Dieuleveult, Benoit Miotto
Feb 2, 2020·Journal of Cell Science·Nadine Sen NkweEl Bachir Affar
Jul 28, 2017·Cellular and Molecular Life Sciences : CMLS·Alireza NoormohammadiDavid Vilchez
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Taylor D HinnantElizabeth T Ables
Sep 9, 2017·Cell Death and Differentiation·Achim Werner, Michael Rape
Jun 14, 2019·Stem Cells International·Bertal H AktasSüleyman Ergün
Sep 15, 2020·The Journal of Biological Chemistry·Rebecca R Florke GeePatrick Ryan Potts
Dec 19, 2020·Cell Death and Differentiation·Mohammed A BasarAchim Werner
May 1, 2018·Seminars in Cell & Developmental Biology·Nicholas S StrandRicardo M Zayas

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