Ubiquitin E3 Ligase MARCH7 promotes proliferation and invasion of cervical cancer cells through VAV2-RAC1-CDC42 pathway

Oncology Letters
Jianguo HuXingwei Jiang

Abstract

Ubiquitin E3 Ligase MARCH7 is involved in T cell proliferation and neuronal development. In our previous study, we demonstrated MARCH7 promoted malignant behavior of ovarian cancer via the nuclear factor (NF)-κB and Wnt/β-catenin signaling pathway. However, the expression and function of MARCH7 in cervical cancer remains unknown. The present study aimed to unravel the expression and function of MARCH7 in cervical cancer to elucidate its potential role in the diagnosis and pathogenesis of cervical cancer. Results indicated that the expression of MARCH7 was abnormally high in cervical cancer tissues than normal cervical tissues. However, silencing the expression of MARCH7 in HeLa cells resulted in decreased cell proliferation and invasion. Mechanistic investigations revealed that MARCH7 interacted with VAV2. Silencing the expression of MARCH7 in HeLa cells inhibited the VAV2-RAC1-CDC42 signaling pathway. Overall, the results of the present study identified MARCH7 as a candidate oncogene in cervical cancer, and a potential target for cervical cancer therapy.

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Citations

Aug 6, 2020·Animals : an Open Access Journal From MDPI·Jun Cao, Xiuzhu Cheng
Aug 23, 2020·International Journal of Molecular Sciences·Takashi ShiromizuYuhei Nishimura

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Datasets Mentioned

BETA
AB10016

Methods Mentioned

BETA
transfection
Co-immunoprecipitation
nucleotide
GTPases

Software Mentioned

SPSS
ANOVE

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