Ubiquitin-free routes into the proteasome

Cellular and Molecular Life Sciences : CMLS
M A Hoyt, Philip Coffino

Abstract

The majority of proteasome substrates identified to date are marked for degradation by polyubiquitinylation. Exceptions to this principle, however, are well documented and can help us understand the process proteasomes use to recognize their substrates. Examples include ornithine decarboxylase, p21/Cip1, TCRalpha, IkappaBalpha, c-Jun, calmodulin and thymidylate synthase. Degradation of these proteins can be completely ubiquitin-independent or coexist with ubiquitin-dependent pathways. Uncoupling degradation from ubiquitin modification may reflect the evolutionary conservation of mechanisms optimized for highly specialized regulatory functions.

Citations

Apr 2, 2011·The Journal of Biological Chemistry·Allen HendersonPhilip Coffino
Jun 3, 2008·The Journal of Biological Chemistry·Chao-Po LinLeroy F Liu
Mar 11, 2011·Molecular & Cellular Proteomics : MCP·Anca F Savulescu, Michael H Glickman
Feb 21, 2006·Antioxidants & Redox Signaling·Diana Poppek, Tilman Grune
Jun 9, 2009·American Journal of Respiratory Cell and Molecular Biology·Asta JurkuvenaiteJames F Collawn
Apr 16, 2013·The Journal of Clinical Investigation·Saleemulla MahammadRobert D Goldman
Dec 31, 2010·BMC Systems Biology·Marc JungbluthChristof Taxis
May 24, 2008·PLoS Pathogens·Christopher James Rold, Christopher Aiken
Mar 25, 2006·Future Oncology·Bruce R Zetter, Ursula Mangold
Oct 21, 2009·Nature Chemical Biology·Erin K SchraderAndreas Matouschek
Aug 9, 2005·Medical Microbiology and Immunology·Georg HäckerSilke F Fischer
May 21, 2013·Biochimica Et Biophysica Acta·Jenny Erales, Philip Coffino
Jun 19, 2008·Biochimica Et Biophysica Acta·Isabelle Jariel-EncontreMarc Piechaczyk
Oct 19, 2007·Seminars in Cell & Developmental Biology·Shahri Raasi, Dieter H Wolf
Jun 27, 2014·FEBS Open Bio·Bruno Ramos-MolinaRafael Peñafiel
Dec 2, 2004·Biochimica Et Biophysica Acta·Dieter H Wolf, Wolfgang Hilt
Apr 25, 2007·Journal of Neuroscience Research·Jesse M HunterGail V W Johnson
Aug 2, 2018·Nature Reviews. Molecular Cell Biology·Adrien Rousseau, Anne Bertolotti
Nov 2, 2005·The Biochemical Journal·Maria Marjorette O PeñaFranklin G Berger
Jan 24, 2014·Nature Reviews. Molecular Cell Biology·Sucharita BhattacharyyaAndreas Matouschek
Sep 2, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abhishek ChandraLing Qin
Apr 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabine HahnUlrich Schubert
Aug 9, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lourds M FernandoAnna K Allen
Oct 21, 2006·Biochemical Society Transactions·R J Mayer, J Fujita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.