Ubiquitin ligases as therapeutic targets in HIV-1 infection

Expert Opinion on Therapeutic Targets
Jörg Votteler, Ulrich Schubert

Abstract

Introduction of highly active antiretroviral therapy has led to a profound reduction in human immunodeficiency virus (HIV) related mortality; although, the complete eradication of the virus from infected individuals has never been achieved. In addition, due to the high mutation and evolution rate, drug-resistant viruses are continuously emerging. Genetically more stable cellular pathways represent attractive targets for innovative antiviral strategies, especially the ubiquitin proteasome system, which regulates various steps in the HIV replication cycle. This review focuses on certain interactions of HIV and E3 ligases as a major player in the ubiquitin proteasome system. Due to the importance in HIV replication, and together with the high substrate specificity, E3 ligases can be considered as bona fide targets to interfere with HIV infection.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J D Etlinger, A L Goldberg
Jun 1, 1990·Virology·D PuttermanV M Vogt
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M HuibregtseP M Howley
Jun 1, 1997·The Journal of Clinical Investigation·D D Ho
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Dec 19, 1998·The EMBO Journal·A Ciechanover
Jul 9, 1999·Reviews in Medical Virology·D E Ott
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L LorickA M Weissman
Dec 28, 1999·Annual Review of Cell and Developmental Biology·R J Deshaies
Jun 29, 2000·Annual Review of Biochemistry·D VogesW Baumeister
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·G TowersO Danos
Oct 29, 2000·Lancet·A Carr, D A Cooper
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·U SchubertJ W Yewdell
Dec 9, 2000·Virology·D E OttU Schubert
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F PrinciottaJ W Yewdell
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·P M Kloetzel
May 2, 2001·The EMBO Journal·A ReymondA Ballabio
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L VerPlankC A Carter
Feb 12, 2002·Journal of Virology·Greg TowersYasuhiro Takeuchi
Apr 23, 2002·Journal of Virology·Eric O Freed
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simone CowanPaul D Bieniasz
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Caroline BesnierGreg Towers
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carsten MünkNathaniel R Landau
Nov 1, 2002·Reviews in Medical Virology·David E Ott
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·David J KatzmannScott D Emr
Jan 30, 2003·The EMBO Journal·Theodora HatziioannouGreg J Towers
Mar 29, 2003·Journal of Virology·Juan Martin-SerranoPaul D Bieniasz

❮ Previous
Next ❯

Citations

Jul 12, 2008·Reviews in Medical Virology·A CalistriG Palù
Jun 9, 2015·Frontiers in Microbiology·Jun-Da ZhuHwa-Chain R Wang
Aug 6, 2014·The Laryngoscope·Timo J AutioOlli-Pekka Alho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.