Ubiquitin-mediated proteolysis: an ideal pathway for systems biology analysis

Advances in Experimental Medicine and Biology
Martin C Rechsteiner

Abstract

Ubiquitin is a small, evolutionarily conserved eukaryotic protein that can be attached to a wide variety of intracellular proteins including itself. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach.

Citations

Jul 4, 2015·Expert Opinion on Investigational Drugs·Massimo GentileSilvia Gentili
Feb 4, 2005·The Journal of Biological Chemistry·Chiaki KatagiriHiroshi Shima
Sep 11, 2009·Leukemia·J J Shah, R Z Orlowski

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