Ubiquitin-proteasome-mediated CREB repressor degradation during induction of long-term facilitation

Journal of Neurochemistry
Sudarshan C UpadhyaAshok N Hegde

Abstract

Abstract Long-term facilitation in Aplysia and other forms of long-term memory in invertebrates and vertebrates require the gene expression cascade induced by cAMP-responsive element binding protein (CREB). Normally, gene expression by CREB is inhibited by repressors. The molecular mechanisms by which the repression is relieved are not understood. Our results show that Aplysia CREB repressor is a substrate for degradation by the ubiquitin-proteasome pathway. Treatment with the facilitatory neurotransmitter 5-hydroxy tryptamine (5-HT) leads to CREB repressor degradation in vivo and the degradation can be blocked by a specific proteasome inhibitor. Our biochemical studies show that attachment of ubiquitin molecules marks the CREB repressor for degradation by the proteasome. Protein kinase C (PKC) stimulates ubiquitination and degradation of the CREB repressor. Our results suggest that proteolytic removal of the CREB repressor is a potential mechanism for controlling gene expression by CREB. Without stimulation, gene expression is suppressed by the CREB repressor. Upon stimulation with 5-HT, PKC is activated, causing enhancement in ubiquitination and degradation of the CREB repressor. Thus, regulation of proteolysis of the CREB re...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Lahav-BaratzA Hershko
Oct 7, 1994·Cell·T TullyM Del Vecchio
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A N HegdeJ H Schwartz
Mar 27, 2002·Nature Neuroscience·Douglas S F LingTodd C Sacktor
Mar 27, 2002·Nature Neuroscience·Eric A DrierJerry C P Yin
Mar 28, 2002·Physiological Reviews·Michael H Glickman, Aaron Ciechanover
Nov 5, 2002·Nature Reviews. Neuroscience·Ashok N Hegde, Aaron DiAntonio
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maurizio GiustettoJames H Schwartz

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Citations

Mar 28, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sheng-Chun MaoPo-Wu Gean
Aug 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sue-Hyun LeeBong-Kiun Kaang
Jun 23, 2010·Learning & Memory·Ashok N Hegde
Mar 29, 2011·Learning & Memory·Rong-Yu LiuJohn H Byrne
Dec 6, 2007·BMC Biochemistry·Sudarshan C Upadhya, Ashok N Hegde
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carole A FarahWayne S Sossin
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diasinou FioravanteJohn H Byrne
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne K HartJohn H Byrne
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rong-Yu LiuJohn H Byrne
Dec 4, 2012·Journal of Clinical and Diagnostic Research : JCDR·Biju Bahuleyan, Satendra Singh
Jan 17, 2014·Experimental Brain Research·Mohammad SeyedabadiReza Rahimian
Jan 19, 2016·Neurobiology of Learning and Memory·Timothy J JaromeFred J Helmstetter
Nov 17, 2010·Brain Research Bulletin·Diasynou Fioravante, John H Byrne
Aug 3, 2010·Biochimica Et Biophysica Acta·Ashok N Hegde, Sudarshan C Upadhya
Oct 24, 2007·Trends in Neurosciences·Ashok N Hegde, Sudarshan C Upadhya
Aug 18, 2004·Progress in Neurobiology·Ashok N Hegde
Dec 15, 2005·Neurochemistry International·Sudarshan C UpadhyaAshok N Hegde
Apr 30, 2013·Neurobiology of Learning and Memory·Timothy J Jarome, Fred J Helmstetter
Jan 5, 2011·Neurobiology of Learning and Memory·Carlos J Rodriguez-OrtizFederico Bermudez-Rattoni
Dec 19, 2014·Frontiers in Molecular Neuroscience·Ashok N HegdeBrenna C Beckelman
Jan 10, 2017·Ageing Research Reviews·Mahesh Shivarama Shetty, Sreedharan Sajikumar
May 22, 2008·Electrophoresis·Berta SunyerGert Lubec
Feb 16, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ashok N Hegde, Sudarshan C Upadhya
May 8, 2019·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Oct 4, 2020·Cerebral Cortex·J ZhangR C Knickmeyer
Jun 28, 2018·Molecular Neurobiology·Ana SaavedraEsther Pérez-Navarro
May 17, 2019·Neuroscience and Biobehavioral Reviews·Fiona LimanaqiFrancesco Fornai
Oct 8, 2021·The Journal of Cell Biology·Wendy A HerbstKelsey C Martin

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