Ubiquitin Regulation: The Histone Modifying Enzyme's Story

Cells
Jianlin WangYadi Wu

Abstract

Histone post-translational modifications influence many fundamental cellular events by regulating chromatin structure and gene transcriptional activity. These modifications are highly dynamic and tightly controlled, with many enzymes devoted to the addition and removal of these modifications. Interestingly, these modifying enzymes are themselves fine-tuned and precisely regulated at the level of protein turnover by ubiquitin-proteasomal processing. Here, we focus on recent progress centered on the mechanisms regulating ubiquitination of histone modifying enzymes, including ubiquitin proteasomal degradation and the reverse process of deubiquitination. We will also discuss the potential pathophysiological significance of these processes.

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Citations

Dec 7, 2019·The Journal of Biological Chemistry·H Karimi KinyamuTrevor K Archer
May 27, 2020·Genetics and Molecular Biology·Jae Eun LeeJung Hwa Kim
Aug 21, 2020·Journal of Neuro-oncology·Amanda R HaltomSoumen Khatua
Jun 16, 2021·Open Biology·Charlotte M FareJames Shorter
Apr 23, 2021·Current Pediatric Reviews·Jayasree Nair, Akhil Maheshwari

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Methods Mentioned

BETA
ubiquitination
acetylation
Histone Acetylation
deubiquitination
phage display

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