Abstract
The roles of ubiquitin-related genes in hepatocellular carcinoma (HCC) have not been thoroughly investigated. This study aimed to systematically examine ubiquitin-related genes and identify subtypes and stratify prognosis of HCC by using ubiquitin-related signatures. Survival, biological processes, tumor microenvironment (TME), and genomic alterations of the HCC subtypes were investigated. Patients with HCC were classified into two subtypes (clusters 1 and 2) with distinct survival outcomes, pathways, and genomic alterations. Cluster 2 had better prognosis than did cluster 1. Hepatitis B, hepatitis C, Janus tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, and natural killer cell-mediated cytotoxicity were enriched in cluster 1. Moreover, cluster 2 had a higher immune score and immune cell infiltrations, whereas cluster 1 had a lower immune score and immune infiltrations. Additionally, mutations, amplifications, and deletions among the phosphatidylinositol 3-kinase (PI3K)-AKT, p53, and receptor tyrosine kinase (RTK)-RAS pathways more frequently occurred in cluster 1, while those among the Hippo, MYC, and Notch signaling pathways were found in cluster 2. Finally, a prognostic signature, consi...Continue Reading
References
Jan 5, 1995·Nature·M ScheffnerJ M Huibregtse
Jul 2, 2002·Nature Medicine·Haidong DongLieping Chen
Jun 7, 2006·Annual Review of Cell and Developmental Biology·Oliver KerscherMark Hochstrasser
Mar 28, 2009·Nature·Mark Hochstrasser
Apr 30, 2010·Bioinformatics·Matthew D Wilkerson, D Neil Hayes
Apr 30, 2011·Genome Biology·Craig H MermelGad Getz
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Oct 16, 2012·Journal of Hepatology·Markus H Heim
Nov 28, 2012·The Lancet Oncology·Armando SantoroCamillo Porta
Dec 12, 2012·Clinical and Vaccine Immunology : CVI·Feng QianRuth R Montgomery
Jan 5, 2013·Science·Andreas ErnstSachdev S Sidhu
Jan 11, 2013·Nature Reviews. Cancer·Mark WadeGeoffrey M Wahl
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Oct 22, 2013·Immunity·Gabriela BindeaJérôme Galon
Jan 9, 2014·Statistics in Medicine·Marine LorentYohann Foucher
Mar 22, 2014·Current Biology : CB·Claire HerideMichael J Clague
May 17, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin IsraelowMatthew J Evans
Aug 31, 2014·Cancer Research·Anupama PalNicholas J Donato
Nov 7, 2014·Nature Medicine·Doris PopovicIvan Dikic
Jan 17, 2015·Cell·Michael S RooneyNir Hacohen
Dec 23, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jianfei Qi, Ze'ev A Ronai
Mar 26, 2016·Cell Research·Kirby N Swatek, David Komander
May 10, 2016·Nature Reviews. Disease Primers·Josep M LlovetGregory Gores
Jul 29, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meiling CuiHong Li
Dec 3, 2016·Oncotarget·Chao Qu, Yaqin Qu
Jan 7, 2017·Viral Immunology·Shan ChengLi-Hua Zeng
Nov 7, 2017·Nucleic Acids Research·Jiaqi ZhouYu Xue
Dec 16, 2017·Nature Reviews. Cancer·Daniela SenftZe'ev A Ronai
Feb 28, 2018·Journal of Hematology & Oncology·Bo HuCheng Huang
Apr 1, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yutaka KurebayashiMichiie Sakamoto
Jun 22, 2018·Biochemical and Biophysical Research Communications·Ying-Hua PanShu-Guang Su
Jul 5, 2018·The New England Journal of Medicine·Ghassan K Abou-AlfaRobin K Kelley
Sep 6, 2018·Bioinformatics·Haohan WangEric P Xing
Oct 21, 2018·Genome Research·Anand MayakondaH Phillip Koeffler
Jun 4, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua WuJian-Ming Li
Jul 25, 2019·Life Sciences·Mingyang Shen, Lin Lin
Nov 5, 2019·Frontiers in Oncology·Wenli LiJun Liu
Nov 7, 2019·Cancers·Juliane LokauChristoph Garbers
Nov 20, 2019·Oncoimmunology·Si YangZhijun Dai
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 19, 2020·Nature Communications·Yanfeng LiuLiang Chen
Feb 26, 2020·Cancers·Manali Dimri, Ande Satyanarayana