Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis

Cancer Science
Chia-Lang FangKai-Yuan Lin

Abstract

Although gastric cancer (GC) is one of the most common cancers, knowledge of its development and carcinogenesis is limited. To date, expression of ubiquitin-specific protease 3 (USP3) in all types of cancer, including GC, is still unknown. The present study explored the involvement of USP3 in the carcinogenesis and prognosis of GC. We measured USP3 expression in normal and GC tissues and cell lines. Correlations between USP3 protein level and clinicopathological parameters, as well as the significance of USP3 protein level for disease-free survival were assessed. Small hairpin RNA technology and transfection were used to investigate the effect of USP3 manipulation on cell proliferation and spreading. Moreover, xenograft proliferation and metastasis were used to explore the influence of USP3 on tumor growth and metastasis in animals. An increase in USP3 expression was observed in GC cells and tissues. The overexpression of USP3 was significantly correlated with several clinicopathological parameters and poor disease-free survival. Multivariate Cox regression analysis showed that the overexpression of USP3 was an independent prognostic biomarker. Silencing of USP3 suppressed GC cell proliferation and spreading in vitro as well as...Continue Reading

References

Jul 6, 1995·The New England Journal of Medicine·C S Fuchs, R J Mayer
Dec 6, 2005·Cell·Sebastian M B NijmanRené Bernards
Nov 6, 2007·Current Biology : CB·Francesco NicassioElisabetta Citterio
Jul 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun YuJoseph J Y Sung
Jul 25, 2009·Lancet·Henk H HartgrinkCornelis J H van de Velde
Jul 25, 2009·Nature Reviews. Molecular Cell Biology·David KomanderSylvie Urbé
Feb 23, 2010·Molecular Cancer·Xiao-Wei ZhangWei-Jian Guo
Feb 2, 2011·PloS One·Chiara LuiseStefano Confalonieri
Oct 19, 2011·Pathology, Research and Practice·Wataru YasuiNaohide Oue
Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi ZengGuo-Hui Fu
Mar 4, 2014·World Journal of Gastroenterology : WJG·Michele OrdituraFerdinando De Vita
Dec 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guang-Yin ZhaoJian-Yong Ding
Jan 7, 2015·Ageing Research Reviews·Maria A ErmolaevaBjörn Schumacher
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 7, 2015·Journal of Cellular and Molecular Medicine·Lei ZhangJianjun Qian
Feb 18, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing QuKunwei Shen
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
May 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Yu GuChang-Zhi Huang
Apr 5, 2016·OncoTargets and Therapy·Min ZhangYuan-Hong Xu
Aug 16, 2016·World Journal of Surgical Oncology·Nick BaniakRani Kanthan
Apr 21, 2017·International Journal of Molecular Sciences·Prasanna Vasudevan Iyengar
Aug 16, 2017·Biochemical and Biophysical Research Communications·Song FuRenhua Lv

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Citations

Jun 28, 2019·American Journal of Clinical Pathology·Yan WangYing Liu
Oct 19, 2019·The Journal of Biological Chemistry·Yingying WuCeshi Chen
Mar 9, 2020·Cancer Chemotherapy and Pharmacology·Parthasaradhireddy TanguturiSuresh Ramakrishna
Jan 4, 2020·Oncology Letters·Jiangang SunYongshun Gao
Aug 23, 2019·Expert Review of Anticancer Therapy·Shunsuke NakamuraYasuhiro Kodera
Jun 27, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiaosheng WuJide Wang
Jun 18, 2021·Frontiers in Cell and Developmental Biology·Iveta GažováKim M Summers
Aug 5, 2021·Oncology Letters·Bilal AlkhizziHani Choudhry
Jan 14, 2022·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chunyan LiuBing Li

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Methods Mentioned

BETA
ubiquitination
deubiquitination
surgical resection
xenograft
PCR
transfection
zymography

Software Mentioned

SPSS

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