Ubiquitination and endocytosis of the high affinity receptor for IgE

Molecular Immunology
Rosa MolfettaRossella Paolini

Abstract

The high affinity receptor for IgE (FcvarepsilonRI) is constitutivelly expressed on the surface of mast cells and basophils as a multimeric complex. Upon antigen ligation to FcvarepsilonRI-bound IgE molecules, the receptor complex transduces intracellular signals leading to the release of preformed and newly synthesised pro-inflammatory mediators. FcvarepsilonRI engagement also generates negative intracellular signals involving the coordinated action of adapters, phosphatases and ubiquitin ligases that limits the intensity and duration of positive signals. Relevant to this, antigen-induced FcvarepsilonRI ubiquitination has become recognized as an important signal for the internalization and delivery of engaged receptor complexes to lysosomes for degradation. In this article, we review recent advances in our understanding of molecular mechanisms that guarantee the clearance of antigen-stimulated FcvarepsilonRI complexes from the cell surface. A particular emphasis will be given on how lipid rafts and the ubiquitin pathway cooperate to ensure receptor internalization and sorting along the endocytic compartments. A brief discussion regarding how ubiquitination regulates the endocytosis of Fc receptors other than FcvarepsilonRI wil...Continue Reading

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Citations

Jun 16, 2012·The Journal of Biological Chemistry·Hae Mi JooJi Young Kim
May 28, 2011·Plant Physiology·G Wilma van EsseSacco C de Vries
Apr 15, 2011·Journal of Lipids·Adriana Maria Mariano Silveira E SouzaConstance Oliver
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Feb 27, 2015·Cellular and Molecular Life Sciences : CMLS·Jeoung-Sook Shin, Alexandra M Greer
Oct 4, 2014·Frontiers in Immunology·Rosa MolfettaRossella Paolini
Mar 2, 2016·Molecular and Cellular Biology·Monika BambouskovaPetr Draber
Jul 12, 2019·Science Translational Medicine·Friederike JönssonPierre Bruhns
Feb 6, 2020·International Journal of Molecular Sciences·Rosa MolfettaRossella Paolini
Feb 13, 2018·Immunological Reviews·Franco H FalconeRonit Sagi-Eisenberg
Aug 6, 2020·International Journal of Molecular Sciences·Mario LecceRossella Paolini

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