PMID: 6977736Jan 22, 1982Paper

Ubiquitous presence of the tailed, asymmetric forms of acetylcholinesterase in the peripheral and central nervous systems of the frog (Rana temporaria)

Neuroscience Letters
M Nicolet, F Rieger

Abstract

Five molecular forms of acetylcholinesterase can be solubilized from the peripheral and central nervous systems of the frog: they will be referred to as the 3.6, 6, 10.5, 14 and 18 S forms. They seem to be analogous to the forms present in endplate-rich and endplate-free regions of frog skeletal muscle. In particular the 18 and 14 S forms represent the collagen-tailed forms of frog acetylcholinesterase. These heavy forms are found in all peripheral and central tissues examined, including whole brain or regions of brain: cerebellum, telencephalon, optic tectum, spinal cord, spinal ventral and dorsal roots and sciatic nerve, as well as in glial or Schwann cellrich tissues devoid of neuronal elements, such as the filum terminale or the severed stump of the nerve, several weeks after section. The 18 S form may represent up to 30% of total acetylcholinesterase activity. It thus seems that the 14 S and 18 S forms are very widely distributed throughout most neuronal and non-neuronal tissues in amphibians.

References

Aug 15, 1978·European Journal of Biochemistry·S Bon, J Massoulié
Jul 20, 1979·Brain Research·F RiegerM L Shelanski
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S BonJ Massoulié
Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R A Andersen, A Mikalsen
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Aug 1, 1985·Developmental Biology·R I Lappin, L L Rubin
Jan 1, 1988·Neurochemistry International·L PezzmentiR J Bradley
Apr 1, 1994·The Journal of Cell Biology·L AnglisterU J McMahan
Dec 30, 1987·European Journal of Biochemistry·I Silman, A H Futerman

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