ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo

European Journal of Pharmacology
Doru Georg Margineanu, E Wülfert

Abstract

Local diffusion of bicuculline from a bicuculline-containing recording micropipette increased the orthodromic field population spike (PS2), elicited upon commissural stimulation in the hippocampal CA3 region of anaesthetized rats. This increase in PS2 was consistently reduced by 5.4 mg/kg of the novel anticonvulsant drug ucb L059 ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide), when injected i.v. 10 min prior to lowering in place the bicuculline-containing micropipette. ucb L059 had no effect on PS2 in the absence of bicuculline. Paired-pulse stimulation produced marked inhibition of the second PS2 at low interstimulus interval, an effect which was significantly reduced by bicuculline. Although ucb L059 reduced the effect of bicuculline on both PS2S elicited by paired stimulations, the drug did not alter the reduction by bicuculline of paired-pulse inhibition at low interstimulus interval. These results suggest that ucb L059 prevents increases in CA3 neuronal excitability by bicuculline through a non gamma-aminobutyric acid-ergic mechanism.

References

Nov 10, 1992·European Journal of Pharmacology·A J GowerE Wülfert
Nov 1, 1981·Neurology·E J HeyerR L Macdonald
Apr 1, 1995·Archives of Physiology and Biochemistry·D G Margineanu, E Wülfert

❮ Previous
Next ❯

Citations

Oct 14, 2003·European Journal of Pharmacology·Michel GillardPierre Chatelain
Apr 16, 2003·European Journal of Pharmacology·Doru Georg Margineanu, Henrik Klitgaard
Apr 23, 1997·European Journal of Pharmacology·G J SillsM J Brodie
Sep 3, 1998·European Journal of Pharmacology·H KlitgaardE Wülfert
Jul 13, 2001·Pharmacology & Therapeutics·P KwanM J Brodie
Feb 2, 2000·Brain Research Bulletin·D G Margineanu, E Wülfert
Dec 4, 2002·Epilepsia·Ali GorjiErwin-Joseph Speckmann
Jul 1, 2008·Therapeutic Advances in Neurological Disorders·Rainer SurgesMatthew C Walker
Nov 21, 2001·Pharmacotherapy·C A Hovinga
Dec 14, 2001·Lancet·S Shorvon
Mar 19, 2002·Neuropharmacology·P Poulain, D G Margineanu
Oct 10, 2013·The European Journal of Neuroscience·Julieta Griselda Mendoza-TorreblancaGisela Gómez-Lira
Feb 5, 2003·Seizure : the Journal of the British Epilepsy Association·Henrik KlitgaardDoru-Georg Margineanu
Nov 3, 2004·Seizure : the Journal of the British Epilepsy Association·Brigitte M Bouwman, Clementina M van Rijn
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D G Margineanu, H Klitgaard
Mar 1, 2009·Therapeutic Advances in Neurological Disorders·Eugen Trinka, Judith Dobesberger
Jul 14, 2004·British Journal of Pharmacology·Tobias LenigerMartin Wiemann
Apr 30, 2019·European Journal of Pharmacology·A Litvinova SvetlanaN Avakyan Gagik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.