UCHL1 /PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch

BioMed Research International
Piotr KupczykJ C Szepietowski

Abstract

Psoriasis is an immunogenetic skin disease manifesting as plaque lesions on the skin. Patients with psoriasis frequently suffer from itch, an unpleasant sensation causing a desire to scratch. Psoriatic itch is mainly transmitted by unmyelinated C-fibers; however, the exact molecular mechanism of psoriatic itch is still unexplained. Protein gene product 9.5 (PGP 9.5) is a panneurological marker commonly used for analysis of peripheral peptidergic and nonpeptidergic nerves and identification of cutaneous neuro-immune-endocrine cells. However, some studies suggested that nonneuronal cells, like keratinocytes, may also express PGP 9.5. This phenomenon might be linked with impaired axonal transport, keratinocyte injury, or dysfunctions of neuro-immune-cutaneous connections. The aim of this study was to analyze the expression of PGP 9.5 in psoriatic skin. We observed significantly altered density of PGP 9.5-positive axonal nerve terminals in pruritic lesional (p=0.04) and nonlesional psoriatic skin (p>0.001) compared with controls. In contrast, no significant differences were observed between psoriatic skin without itch and controls. Furthermore, PGP 9.5 expression by suprabasal keratinocytes (SBKs) was significantly increased in itc...Continue Reading

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Citations

Nov 3, 2020·Frontiers in Immunology·Xuan Zhang, Yanling He
Jul 18, 2021·Scientific Reports·Pedro Rodríguez-JiménezHortensia de la Fuente

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Methods Mentioned

BETA
biopsy
biopsies
PCR
Assay
Protein Assay
electrophoresis
confocal microscopy
ubiquitination

Software Mentioned

GraphPad Prism
ProbeFinder
AxioVision
Fiji
Statistica
LibreOffice
GraphPad

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