UDP-glucuronosyltransferases in the metabolic disposition of xenobiotics

Drug Metabolism Reviews
T R TephlyM D Green

Abstract

UDPGT isoenzymes are products of multiple gene families as demonstrated by sequence analysis of purified proteins and by molecular cloning experiments. These isoenzymes are relatively specific for endogenous substrates but have broad substrate specificities for xenobiotic substrates. They are important metabolic enzymes capable of converting exogenous and endogenous substances to more hydrophilic metabolites. Each species has its own pattern of UDPGTs and it is not possible at this time to extrapolate information directly from one species to another.

References

Mar 1, 1987·The Biochemical Journal·M R JacksonB Burchell
Nov 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T TephlyY Irshaid
Jul 1, 1981·Archives of Biochemistry and Biophysics·R H Tukey, T R Tephly
Sep 1, 1980·Tubercle·G Acocella, R Conti
Sep 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M PacificiA R Boobis

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Citations

Nov 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R G DickinsonA R King
May 1, 1991·The Journal of Pharmacy and Pharmacology·Z Ben-ZviJ Kaplanski
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Hoyumpa, S Schenker
Jan 1, 1993·Pharmacology & Toxicology·J Sonne
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonA G Renwick
Jul 1, 1990·Trends in Pharmacological Sciences·T R Tephly, B Burchell

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