UFLC-ESI-MS/MS analysis of multiple mycotoxins in medicinal and edible Areca catechu

Chemosphere
Hongmei LiuMei-Hua Yang

Abstract

A robust, sensitive and reliable ultra fast liquid chromatography combined with electrospray ionization tandem mass spectrometry (UFLC-ESI-MS/MS) was optimized and validated for simultaneous identification and quantification of eleven mycotoxins in medicinal and edible Areca catechu, based on one-step extraction without any further clean-up. Separation and quantification were performed in both positive and negative modes under multiple reaction monitoring (MRM) in a single run with zearalanone (ZAN) as internal standard. The chromatographic conditions and MS/MS parameters were carefully optimized. Matrix-matched calibration was recommended to reduce matrix effects and improve accuracy, showing good linearity within wide concentration ranges. Limits of quantification (LOQ) were lower than 50 μg kg(-1), while limits of detection (LOD) were in the range of 0.1-20 μg kg(-1). The accuracy of the developed method was validated for recoveries, ranging from 85% to 115% with relative standard deviation (RSD) ≤14.87% at low level, from 75% to 119% with RSD ≤ 14.43% at medium level and from 61% to 120% with RSD ≤ 13.18% at high level, respectively. Finally, the developed multi-mycotoxin method was applied for screening of these mycotoxins...Continue Reading

References

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Citations

Apr 17, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Weilu ZhouMeihua Yang
Sep 7, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jia'an QinMeihua Yang
Sep 27, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sisi ZhangShen Ji
Jun 6, 2018·Frontiers in Pharmacology·Dandan KongMeihua Yang
Aug 3, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yanwei FuJiaoyang Luo
Apr 26, 2021·Analytica Chimica Acta·Vicente Antonio Mirón-MéridaFrancisco M Goycoolea
Jun 20, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dan-Tong ZhaoRong Rong

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