UFT as maintenance therapy in patients with advanced colorectal cancer responsive to the FOLFOX4 regimen

Oncology
R ScalamognaG R Corazza

Abstract

In advanced colorectal cancer (ACC), FOLFOX4 has been accepted as a standard chemotherapeutic regimen. Due to the neurotoxicity induced by oxaliplatin, which occurs in about 50% of patients during the 6-month FOLFOX4 regimen, and the frequent need for hospitalization, alternative regimens may be required. We aimed to determine whether a 'maintenance' therapy with oral UFT (uracil-tegafur) in patients responding to FOLFOX4 is able to maintain the response and improve the quality of life (QoL) as a result of the outpatient regimen and lower psychological distress. Untreated patients with ACC who did not progress after 6 months of FOLFOX4 received oral UFT until disease progression or unacceptable toxicity. The aim of the study was to maintain the response obtained with the FOLFOX4 regimen for at least 6 months. The secondary objective was to evaluate QoL during the two different treatment regimens utilizing the 36-item Short Form Health Survey (SF-36). From January 2003 to August 2004, out of the enrolled 30 patients [22 males and 8 females; 2 patients with a complete response (CR), 14 patients with a partial response (PR) and 6 patients in stable disease (SD) after 6 months of FOLFOX4] 22 continued therapy with UFT until progres...Continue Reading

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Citations

Apr 2, 2009·Current Oncology Reports·Robin Kelley, Alan P Venook
Sep 17, 2011·The Journal of Medical Investigation : JMI·Hisatsugu GotoYasuhiko Nishioka
Dec 18, 2013·Phytotherapy Research : PTR·Menghua ChenAnthony L Zhang
Dec 8, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Toshikazu MoriwakiIchinosuke Hyodo

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