UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Chemical Communications : Chem Comm
Junbin HeMin Ye

Abstract

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

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Citations

Nov 6, 2018·Journal of Agricultural and Food Chemistry·Yu-Jia Zhao, Chun Li

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Methods Mentioned

BETA
glycosylation
glucosylation
NMR

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