UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.

FEBS Letters
Mai NagatoshiHajime Mizukami

Abstract

Crocin is an apocarotenoid glycosyl ester accumulating in fruits of Gardenia jasminoides and used as a food coloring and nutraceutical. For the first time, the two glucosyltransferases UGT75L6 and UGT94E5 that sequentially mediate the final glucosylation steps in crocin biosynthesis in G. jasminoides have been identified and functionally characterized. UGT75L6 preferentially glucosylates the carboxyl group of crocetin yielding crocetin glucosyl esters, while UGT94E5 glucosylates the 6' hydroxyl group of the glucose moiety of crocetin glucosyl esters. The expression pattern of neither UGT75L6 nor UGT94E5 correlated with the pattern of crocin accumulation in G. jasminoides.

References

Jan 1, 1994·DNA Sequence : the Journal of DNA Sequencing and Mapping·J Hughes, M A Hughes
Oct 24, 2000·The Journal of Biological Chemistry·R G JacksonD J Bowles
Oct 20, 2001·The Journal of Biological Chemistry·Eng-Kiat LimDianna J Bowles
Apr 30, 2005·Current Opinion in Plant Biology·Dianna BowlesBrigitte Poppenberger
Apr 27, 2007·Nature·Christopher J ThibodeauxHung-wen Liu
May 23, 2007·Nucleic Acids Research·Paul HortonKenta Nakai
Oct 11, 2007·BMC Plant Biology·Nunzio D'AgostinoGiovanni Giuliano
Jul 10, 2008·The Journal of Biological Chemistry·Angela RubioLourdes Gómez-Gómez
Jul 30, 2011·The Journal of Biological Chemistry·Mai NagatoshiHajime Mizukami
Aug 23, 2011·Nature Chemical Biology·Richard W GanttJon S Thorson

❮ Previous
Next ❯

Citations

May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lan Gao, Bi-Yun Zhu
Aug 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sarah FruscianteGiovanni Giuliano
Jul 3, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hajime Mizukami
Oct 6, 2017·Journal of Experimental Botany·Oussama AhrazemLourdes Gómez-Gómez
Jul 7, 2019·Microbial Cell Factories·Wen WangChanghao Bi
Apr 27, 2017·Frontiers in Plant Science·Aijia JiJingyuan Song
Oct 3, 2018·Bioscience, Biotechnology, and Biochemistry·Aki YamadaKazuyoshi Terasaka
Nov 20, 2020·Computational and Structural Biotechnology Journal·Taoli LiuQinlong Zhu
Jun 2, 2021·Horticulture Research·Xiaoyang XuYongheng Yang
Oct 9, 2020·Current Opinion in Biotechnology·Jie ShaoYong Wang
Oct 24, 2018·Journal of Agricultural and Food Chemistry·Fangyu DingBingfang He
Mar 29, 2020·ACS Synthetic Biology·Xiangdong PuJingyuan Song
Aug 28, 2021·International Journal of Molecular Sciences·Alberto José López-JimenezLourdes Gómez-Gómez
Sep 7, 2021·Natural Product Reports·Elisabeth KurzeWilfried Schwab

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.