UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer

Breast Cancer Research and Treatment
Wei JinZhi-ming Shao

Abstract

BRCA1 is closely related to the pathogenesis of breast cancer, BRCA1 mRNA is reduced in sporadic breast cancer cells despite the lack of mutations. In the present report, we found that overexpression of UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) was closely related to DNA methylation, deacetylation, and methylation of histones, recruitment of an inhibiting transcriptional complex on the BRCA1 promoter in sporadic breast cancer. Overexpression of UHRF1 induced deacetylation of histones H3 and H4, which was facilitated by recruitment of histone deacetylase1 (HDAC1) to the BRCA1 promoter. Loss of acetylation was accompanied by loss of binding of the key transcription factors MyoD, CBP, and p300. UHRF1 also recruited histone lysine methyltransferase G9a to the BRCA1 promoter and histone 3 lysine 4 (H3K4) was demethylated, and histone 3 lysine 9 (H3K9) was methylated. Finally, overexpression of UHRF1 leaded to methylation of BRCA1 promoter by recruitment of DNMT1 to the BRCA1 promoter, locking in marked suppression of BRCA1. It is the first to describe that UHRF1 is responsible for regulating BRCA1 transcription by inducing DNA methylation, histone modifications, and recruitment of transcriptional complex on th...Continue Reading

References

Dec 19, 1996·Nature·A J Bannister, T Kouzarides
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C A HassigS L Schreiber
Feb 8, 2000·The Journal of Biological Chemistry·A WangD G Johnson
Jul 8, 2000·The Journal of Biological Chemistry·T K MacLachlanW S El-Deiry
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BegerF Wong-Staal
Mar 30, 2001·The Journal of Biological Chemistry·N Vo, R H Goodman
Feb 1, 2003·Breast Cancer Research : BCR·Christopher R Mueller, Calvin D Roskelley
Aug 12, 2003·The Journal of Biological Chemistry·Matthew J OberleyPeggy J Farnham
Mar 23, 2004·Annals of the New York Academy of Sciences·Abdul-Qader AbbadyMarc Mousli
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gangning LiangPeter A Jones
Oct 29, 2004·Nature Reviews. Cancer·Nicholas TurnerAlan Ashworth
Nov 3, 2004·Cancer Research·Insoo BaeEliot M Rosen
Jun 23, 2005·Cell Cycle·Tibor RauchXingzhi Xu
Aug 4, 2007·Science·Magnolia BostickSteven E Jacobsen
Dec 6, 2008·Nucleic Acids Research·Jong Kyong KimSriharsa Pradhan
Dec 17, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Hideharu HashimotoXiaodong Cheng

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Citations

May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Feng YanMing-Chen Zhu
Jun 15, 2011·Molecular and Cellular Biology·Yuhong LuPeter M Glazer
Nov 12, 2010·International Journal of Radiation Biology·Xinli LiSaijun Fan
Dec 19, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Aileen BahlMiina Ollikainen
Feb 26, 2011·Cancer·Alexandros DaskalosTriantafillos Liloglou
Oct 2, 2015·Genes·Shaliny RamachandranEster M Hammond
Aug 4, 2015·Biochemical and Biophysical Research Communications·Soon Young JangJong-Ho Kim
Dec 4, 2012·Biochemical and Biophysical Research Communications·Mayada AchourChristian Bronner
Jun 20, 2015·Journal of the National Cancer Institute·Sin-Aye ParkJa Seok Koo
Feb 4, 2014·Cancer Cell·Raksha MudbharyKirsten C Sadler
Jan 29, 2013·Acta Biochimica Et Biophysica Sinica·Qiaoqiao WangWei Jin
Nov 7, 2017·Nutrients·Guilherme Felipe Santos FernandesJean Leandro Dos Santos
Jun 3, 2010·British Journal of Cancer·M UnokiY Nakamura
Apr 17, 2019·Journal of Cellular Physiology·Mengxuan ZhuBinbin Liu
Jul 20, 2019·Chemistry : a European Journal·Liliyana ZaayterYves Mély
Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justin M RectenwaldKenneth H Pearce
Jul 1, 2016·Oncotarget·Samrat Roy ChoudhuryJoseph Irudayaraj
Dec 30, 2017·Oncology Letters·Hani ChoudhryMahmoud Alhosin
Oct 2, 2012·Oncology Reports·Yasuhide KofunatoSeiichi Takenoshita
Nov 15, 2016·Journal of Experimental & Clinical Cancer Research : CR·Mahmoud AlhosinChristian Bronner
Feb 22, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Harsimran Sidhu, Neena Capalash
Mar 23, 2018·SLAS Discovery·Guillermo SenisterraMasoud Vedadi

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