UHRF1 suppression promotes cell differentiation and reduces inflammatory reaction in anaplastic thyroid cancer

Oncotarget
Bi-Cheng WangQuentin Liu

Abstract

Anaplastic thyroid cancer (ATC), an undifferentiated subtype of thyroid cancer, is one of the most malignant endocrine cancer with low survival rate, and resistant to chemotherapy and radiation therapy. Here we found that UHRF1 was highly expressed in human ATC compared with normal tissue and papillary thyroid cancer (PTC). Knockdown of UHRF1 inhibited proliferation of ATC in vitro and in vivo. Consistently, overexpression of UHRF1 promoted the proliferation of thyroid cancer cells. Moreover, UHRF1 suppression induced differentiation of three-dimensional (3D) cultured ATC cells and down-regulated the expression of dedifferentiation marker (CD97). The stem cell markers (Sox2, Oct4 and Nanog) were suppressed simultaneously. In addition, UHRF1 knockdown reduced the transcription of cytokines (IL-8, TGF-α and TNF-α), which might relieve the inflammatory reaction in ATC patients. This study demonstrated a role of UHRF1 in ATC proliferation, dedifferentiation and inflammatory reaction, presenting UHRF1 as a potential target in ATC therapy.

References

Sep 9, 1993·International Journal of Cancer. Journal International Du Cancer·P L LolliniG Palmieri
Jun 28, 2000·European Journal of Endocrinology·C Schmutzler, J Koehrle
Dec 13, 2003·Autoimmunity·R A Ajjan, A P Weetman
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Renaud De CrevoisierMartin Schlumberger
Mar 2, 2005·Cancer·Electron KebebewAlex McMillan
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Wen T Shen, Woong-Youn Chung
Mar 25, 2006·Nature Reviews. Cancer·Tetsuo KondoSylvia L Asa
Apr 11, 2006·Molecular Cancer Research : MCR·Haitian LuChuanshu Huang
Jul 31, 2007·Pharmacology & Therapeutics·Christian BronnerValérie B Schini-Kerth
Dec 6, 2008·Nucleic Acids Research·Jong Kyong KimSriharsa Pradhan
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bharat B AggarwalBokyung Sung
Jun 6, 2009·British Journal of Cancer·M UnokiR Hamamoto
Apr 13, 2010·Cytokine·Franco LumachiRocco Orlando
Jun 3, 2010·British Journal of Cancer·M UnokiY Nakamura
Jan 5, 2011·Cell Metabolism·Rebecca G BakerSankar Ghosh
Feb 26, 2011·Annals of the Rheumatic Diseases·Helia B SchonthalerErwin F Wagner
Feb 26, 2011·Cancer·Alexandros DaskalosTriantafillos Liloglou
May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Feng YanMing-Chen Zhu
Nov 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Robert C SmallridgeUNKNOWN American Thyroid Association Anaplastic Thyroid Cancer Guidelines Taskforce
Nov 20, 2012·Surgery·Electron Kebebew
Apr 17, 2013·The Journal of Clinical Endocrinology and Metabolism·R C SmallridgeR Von Roemeling
Jul 23, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jirka GrosseDaniela Grimm
Aug 15, 2013·Molecular Biology Reports·Congrong YangYunjie Cheng
Aug 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lin ZhouKaichun Wu
Feb 4, 2014·Cancer Cell·Raksha MudbharyKirsten C Sadler

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE9115
GSE33630

Methods Mentioned

BETA
xenograft
PMA
PCR
electrophoresis

Software Mentioned

GraphPad Prism
GEO2R
SPSS

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Thyroid : Official Journal of the American Thyroid Association
Valeria CarinaCarla Giordano
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Hyeon Jin KimJae Kyung Myung
European Review for Medical and Pharmacological Sciences
Z-Y ZhangW-T Yuan
© 2022 Meta ULC. All rights reserved