UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication

Bioorganic & Medicinal Chemistry Letters
Dawn N WardPaul J Smith

Abstract

The bacterial natural product UK-1 and several structural analogs inhibit replication of the hepatitis C virus in the replicon assay, with IC50 values as low as 0.50 μM. The NS3 helicase has been identified as a possible target of inhibition for several of these compounds, while the remaining inhibitors act via an undetermined mechanism. Gel shift assays suggest that helicase inhibition is a direct result of inhibitor-enzyme binding as opposed to direct RNA binding, and the ATPase activity of NS3 is not affected. The syntheses and biological results are presented herein.

References

Sep 20, 2008·Bioorganic & Medicinal Chemistry·Anna Stankiewicz-DrogonAnna M Boguszewska-Chachulska
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simone SusserChristoph Sarrazin

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Citations

Jan 26, 2016·Bioorganic & Medicinal Chemistry Letters·Daniel C TalleyPaul J Smith
May 27, 2017·Microbial Cell Factories·Armando A LosadaCarlos Olano
Nov 20, 2020·ChemMedChem·Abigail C JacksonKatherine J Franz

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