UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates.

Emerging Microbes & Infections
K RosenkeH Feldmann

Abstract

The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases.

References

Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
May 13, 2020·Nature·Vincent J MunsterEmmie de Wit
May 22, 2020·Science·Jingyou YuDan H Barouch
Jun 10, 2020·Nature·Brandi N WilliamsonEmmie de Wit
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster
Oct 29, 2020·Communications Biology·Amanda D MelinJames P Higham
Nov 11, 2020·The American Journal of Pathology·Robert V BlairJay Rappaport
Dec 1, 2020·Emerging Microbes & Infections·Kyle RosenkeHeinz Feldmann
Dec 18, 2020·BMJ : British Medical Journal·Jacqui Wise
Dec 20, 2020·Nature Microbiology·Dhiraj Kumar SinghDeepak Kaushal
Jan 13, 2021·Science Translational Medicine·Emily SperanzaEmmie de Wit
Feb 11, 2021·MedRxiv : the Preprint Server for Health Sciences·Nicholas G DaviesRuth H Keogh
Mar 5, 2021·Science·Nicholas G DaviesW John Edmunds
Mar 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Paolo CalistriAlessio Lorusso
Mar 17, 2021·Nature·Nicholas G DaviesRuth H Keogh
Mar 20, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Daniel J GrintRosalind M Eggo
Mar 27, 2021·Nature·Erik VolzNeil M Ferguson
Apr 17, 2021·Cell·Nicole L WashingtonKristian G Andersen
Apr 21, 2021·The American Journal of Tropical Medicine and Hygiene·Elaine HaddockHeinz Feldmann
Jun 11, 2021·MMWR. Morbidity and Mortality Weekly Report·Prabasaj PaulBenjamin J Silk
Jul 29, 2021·Science Translational Medicine·Neeltje van DoremalenVincent J Munster
Aug 13, 2021·BioRxiv : the Preprint Server for Biology·Vincent J MunsterEmmie de Wit

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Citations

Mar 3, 2022·The Journal of Microbiology·Young-Il KimYoung Ki Choi

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