Ulceration of the oral mucosa induced by antidepressant medication: a case report.

Journal of Medical Case Reports
Fernanda BertiniJanete Dias Almeida

Abstract

Ulcers are frequent lesions of the oral mucosa. Generally, they are circumscribed round or elliptical lesions surrounded by an erythematous halo and covered with an inflammatory exudate in their central portion, and are accompanied by painful symptoms. Oral ulcers affect 20% of the population, especially adolescents and young adults. The etiopathogenesis includes immunological alterations, infections, nutritional deficiency, trauma, food and contact allergies, autoimmune diseases, neoplasms, and psychosomatic, genetic and environmental factors. A 78-year-old Caucasian woman was referred by her dentist to our outpatient clinic with a 4-week history of an oral ulceration after using an antidepressant (sertraline hydrochloride). On the basis of the clinical findings and anamnesis, the occurrence of the lesion was attributed to the use of the drug. Exfoliative cytology was performed, to reassure the patient that it was not oral cancer, which revealed the presence of a nonspecific inflammatory reaction. The drug was replaced and resolution of symptoms was observed. Exfoliative cytology should be the complementary examination of choice in cases of oral ulcers with a suspicion of drug interaction. Although this is a rare event in dent...Continue Reading

References

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Citations

Dec 17, 2015·Phytotherapy Research : PTR·Ramesh PothurajuShaik Abdul Hussain
Nov 7, 2018·The Mental Health Clinician·William OlsufkaRebecca Kavanagh

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Methods Mentioned

BETA
biopsy

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