Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

Bone Marrow Transplantation
K KoikeY Niitsu

Abstract

A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT). Antibiotic-resistant bloody diarrhea, and fever developed 110 days after transplant. Blood and stool cultures were negative. Skin rash was not observed. Barium enema and colonoscopy showed typical features of pancolonic-type ulcerative colitis (UC). Endoscopic biopsies confirmed the diagnosis of UC. Mesalazine and immunosuppressive therapy improved symptoms dramatically. We detected serum antibodies against synthetic tropomyosin (TM) peptide when UC was diagnosed. We postulate that autoimmunity including autoreactive anti-TM antibodies may be involved in the pathogenesis of UC after autologous PBSCT in this patient.

Citations

Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Sagus SampathJeffrey Wong
May 10, 2013·Inflammatory Bowel Diseases·Sansrita NepalBo Shen
Jan 15, 2008·Autoimmunity Reviews·Toshiyuki BohgakiTakao Koike
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May 30, 2006·The British Journal of Dermatology·S WahieS J Meggit
Jan 27, 2017·International Journal of Molecular Sciences·Tae-Hoon ShinKyung-Sun Kang
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Jan 18, 2018·Immunotherapy·Valeria Rios RodriguezDenis Poddubnyy
Aug 11, 2020·Gastroenterology·Al-Qasim Al-BahlaniLara Hart

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