PMID: 9192058Mar 1, 1997Paper

Ulcerative colitis: an epithelial disease?

Baillière's Clinical Gastroenterology
P R Gibson

Abstract

There is now considerable evidence that abnormalities of the structure and function of the colonic epithelium are present in patients with ulcerative colitis and that many of these may occur independently of mucosal inflammation. It is proposed that epithelial abnormalities are the central defect that underlie the development of mucosal inflammation and its chronicity. A simple model for pathogenesis is proposed in which inflammation develops only when epithelial barrier function is impaired to an extent which permits the influx of luminal pro-inflammatory molecules to the lamina propria. Several candidate hypotheses regarding the molecular basis for the abnormality are addressed. The mechanism by which the barrier function is critically impaired involves the interaction of the abnormal epithelium with luminal, mucosal and systemic factors. Focusing on the epithelium would potentially lead to a conceptually different management approach and the development of novel therapeutic strategies.

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Citations

Nov 8, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Kantrol Kumar SahuRavi Shankar Pandey
Apr 16, 2002·European Journal of Clinical Investigation·G KoliosE Kouroumalis
Dec 1, 2000·Scandinavian Journal of Gastroenterology·A VenkatramanS Murthy
Dec 3, 1999·Scandinavian Journal of Gastroenterology·A VenkatramanA B Pulimood
May 8, 2001·European Journal of Gastroenterology & Hepatology·N P MichellM J Langman
Jan 5, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Peter M Irving, Peter R Gibson
Aug 14, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·William E W Roediger
Mar 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aparna VenkatramanSusama Patra

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