PMID: 9192059Mar 1, 1997Paper

Ulcerative colitis: an immunological disease?

Baillière's Clinical Gastroenterology
G Radford-Smith

Abstract

Ulcerative colitis is an inflammatory disease of the large intestine of unknown aetiology. The nature of the inflammatory infiltrate together with the response to corticosteroids suggests that an abnormal immune response is at work. The key question of whether the immune system is responding to an abnormal breach in the mucosa due to another primary abnormality or whether the primary defect lies within the immune response itself has not been answered. Thus far, it is clear that both T and B cell compartments are involved in the persistence of inflammation but the initial interactions that take place in the mucosa in terms of antigen processing and presentation have not been adequately investigated. Those critical steps and potential defects that push T cells and B cells into a heightened state of activation need to be identified.

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Citations

Jan 19, 2012·World Journal of Gastroenterology : WJG·Lino PoleseStefano Merigliano
Mar 21, 2007·International Journal of Colorectal Disease·Lino PoleseImerio Angriman
Apr 18, 2001·Scandinavian Journal of Gastroenterology·P D ThomasP J Ciclitira
Sep 9, 2005·World Journal of Gastroenterology : WJG·Lino PoleseDavide-F D'Amico
Jun 25, 2004·Genes and Immunity·R EriG L Radford-Smith
Apr 16, 2002·European Journal of Gastroenterology & Hepatology·Lino PoleseDavide F D'Amico
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin Winkler-PickettJohn R Ortaldo
Jan 10, 1998·The American Journal of Clinical Hypnosis·D W Schafer

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