Ulinastatin administration is associated with a lower incidence of acute kidney injury after cardiac surgery: a propensity score matched study

Critical Care : the Official Journal of the Critical Care Forum
Xin WanChangchun Cao

Abstract

Systemic inflammation is involved in the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), possesses a variety of anti-inflammatory effects. Therefore, we hypothesized that the administration of ulinastatin would reduce the occurrence of AKI in patients undergoing cardiac surgery with CPB. A retrospective propensity score matched analysis was used to evaluate the effect of ulinastatin on the development of AKI in patients undergoing first documented cardiac surgery with CPB between January 2008 and December 2012 in our hospital. Multiple logistic regression models were also employed to identify the association between UTI administration and development of AKI. A total of 2072 patients who underwent cardiac surgery with CPB met the inclusion criteria. Before propensity score matching, variables such as age, baseline creatinine, CPB duration, red blood cells transfused, and hematocrit were statistically different between the ulinastatin (UTI) group and the control group. On the basis of propensity scores, 409 UTI patients were successfully matched to the 409 patients from among those 1663 patients without UTI administration. After prop...Continue Reading

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Citations

Jul 2, 2016·Critical Care : the Official Journal of the Critical Care Forum·Patrick M Honore, Herbert D Spapen
Jun 4, 2016·Current Opinion in Critical Care·Or Goren, Idit Matot
Nov 22, 2018·World Journal of Emergency Surgery : WJES·Shaoyun LiuMao Zhang
Feb 6, 2017·Internal Medicine·Xiangcheng XieChangchun Cao
Apr 27, 2016·Critical Care : the Official Journal of the Critical Care Forum·Fu-Shan XueChao Sun

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

MatchIt
SPSS
R

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