Ulipristal acetate: in uterine fibroids.

Drugs
Jamie D Croxtall

Abstract

Ulipristal acetate, a selective progesterone-receptor modulator, inhibits the proliferation and induces apoptosis of leiomyoma cells in vitro. It also modulates the expression of vascular endothelial growth factors and hormone receptors and modulates extracellular matrix breakdown in leiomyoma cells but not in myometrial cells. In two randomized, double-blind, multinational phase III trials of 13 weeks' duration in women aged 18-50 years with uterine fibroids, a once-daily regimen of oral ulipristal acetate 5 mg/day controlled excessive uterine bleeding (primary endpoint) in ≥90% of patients. Ulipristal acetate 5 mg/day was more effective than placebo and was shown to be noninferior to intramuscular leuprolide acetate 3.75 mg once monthly in controlling uterine bleeding. Uterine bleeding was rapidly controlled by ulipristal acetate. Approximately half of recipients of ulipristal acetate 5 mg/day became amenorrhoeic within the first 10 days of treatment. Furthermore, uterine bleeding was controlled significantly more rapidly for recipients of ulipristal acetate than recipients of leuprolide acetate. A significantly greater median reduction from baseline in total fibroid volume was observed for recipients of ulipristal acetate 5 ...Continue Reading

References

Oct 1, 1981·Fertility and Sterility·V C Buttram, R C Reiter
Jan 1, 1995·American Journal of Obstetrics and Gynecology·M S ReinA J Friedman
Sep 18, 1998·Human Reproduction·O CohenR Homburg
Feb 24, 2001·Human Reproduction Update·A H Ligon, C C Morton
Jun 4, 2002·Human Reproduction·J Donnez, P Jadoul
Sep 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincenzo De LeoFelice Petraglia
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Donna Day BairdJoel M Schectman
Jun 27, 2003·Environmental Health Perspectives·Gordon P FlakeDarlene Dixon
Mar 1, 2006·Obstetrics and Gynecology Clinics of North America·Peter E Schwartz, Michael G Kelly
May 26, 2006·American Journal of Obstetrics and Gynecology·Michael FlynnEvan Myers
May 17, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Takeshi Maruo
Jul 17, 2007·Human Reproduction Update·Frances McFarland Horne, Diana L Blithe
Jul 31, 2007·Fertility and Sterility·William H Parker
Sep 6, 2007·The Journal of Clinical Endocrinology and Metabolism·Ping YinSerdar E Bulun
Feb 5, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·George L MutterDiana L Blithe
Feb 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Anna V HoekstraJ Julie Kim
Mar 3, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Axelle PintiauxJean-Michel Foidart
Jul 16, 2009·Current Opinion in Obstetrics & Gynecology·Irving M Spitz
Apr 9, 2010·Endocrinology·Hiroshi IshikawaTakeshi Kurita
May 17, 2011·Drugs·Kate McKeage, Jamie D Croxtall
Sep 6, 2011·International Journal of Women's Health·Nirmala Duhan
Feb 3, 2012·The New England Journal of Medicine·Jacques DonnezUNKNOWN PEARL I Study Group
Feb 3, 2012·The New England Journal of Medicine·Jacques DonnezUNKNOWN PEARL II Study Group
Feb 3, 2012·The New England Journal of Medicine·Elizabeth A Stewart

❮ Previous
Next ❯

Citations

Nov 20, 2012·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·María José MunuceLuis Bahamondes
May 25, 2016·Current Obstetrics and Gynecology Reports·P Purohit, K Vigneswaran
Sep 14, 2017·Drugs·Karly P Garnock-Jones, Sean T Duggan
Jul 15, 2017·Journal of Obstetrics and Gynaecology of India·Chandrashekhar V Hegde
May 28, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mohamed GhonimAshraf Nabhan
Aug 20, 2020·Fundamental & Clinical Pharmacology·Claire Le CorvaisierSylvain Goutelle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Philippe Bouchard
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Alistair R W WilliamsAlex Ferenczy
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Vikram Sinai Talaulikar, Isaac Manyonda
The New England Journal of Medicine
Jacques DonnezPEARL II Study Group
© 2021 Meta ULC. All rights reserved