Ultimate tensile strength of PDL of molars in rats after 1-hydroxyethylidene-1,1-bisphosphonate injections

Journal of Dentistry
I AlatliL Hammarström

Abstract

Administration during root formation of a bisphosphonate, 1-hydroxyethylidene-1,1-bisphosphonate (HEBP), at a dose corresponding to 10 mg P/kg body weight, has been found to interfere with the formation of acellular cementum in rats. The purpose of this study was to measure the force required to extract a tooth lacking normal acellular cementum, and to correlate this force and the ultimate periodontal strength with the morphology of the periodontal tissues at different time intervals after single or multiple injections of HEBP. A single injection of HEBP given during root formation inhibited the formation of acellular cementum and resulted in a temporary reduction of the extraction force and the ultimate tensile strength. Ninety days after the injection of HEBP, both parameters were the same as in the controls. The increase in extraction force and ultimate tensile strength was associated with the onset of occlusal contact of the teeth. The organization of periodontal ligaments was improved after the teeth reached the occlusal level. After daily injections of HEBP for 3 days, there was a permanent reduction in root length and dento-alveolar ankylosis developed in the furcation area. (1) A single or three injections of HEBP chang...Continue Reading

References

Aug 1, 1989·Calcified Tissue International·P R Wesselink, W Beertsen
Feb 1, 1985·Endodontics & Dental Traumatology·L AnderssonL Hammarstrom
Aug 1, 1994·Journal of Clinical Periodontology·P R Wesselink, W Beertsen
Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouJ E Davies

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Citations

Jun 21, 2007·L' Orthodontie française·Agnès S Kamoun-Goldrat, Martine F Le Merrer
Jun 16, 2010·Journal of Dentistry·Alejandro Iglesias-LinaresMiguel Angel González Moles
May 13, 2008·European Journal of Oral Sciences·Agnès Kamoun-GoldratMartine Le Merrer
Jul 2, 2016·Journal of Periodontal Research·C-H BaeE-S Cho

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