Ultra-early response assessment in lymphoma treatment: [18 F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment

European Journal of Nuclear Medicine and Molecular Imaging
Marius E MayerhoeferAlexander R Haug

Abstract

To determine whether, in patients with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL), [18F]FDG PET/MR can capture treatment effects within the first week after treatment initiation, and whether changes in glucose metabolism and cell density occur simultaneously. Patients with histologically proven HL or NHL were included in this prospective IRB-approved study. Patients underwent [18F]FDG PET/MR before, and then 48-72 h after (follow-up 1, FU-1) and 1 week after (FU-2) initiation of the first cycle of their respective standard chemotherapy (for HL) or immunochemotherapy (for NHL). Standardized [18F]FDG uptake values (SUVmax, SUVmean) and apparent diffusion coefficients (ADCmin, ADCmean) based on diffusion-weighted MRI, and metabolic and morphological tumour volumes (MTV, VOL) were assessed at each time-point. Multilevel analyses with an unstructured covariance matrix, and pair-wise post-hoc tests were used to test for significant changes in SUVs, ADCs, MTVs and VOLs between the three time-points. A total of 58 patients (11 with HL and 47 with NHL) with 166 lesions were analysed. Lesion-based mean rates of change in SUVmax, SUVmean, ADCmin, ADCmean, MTV and VOL between baseline and FU-1 were -46.8%, -33.3%, +20.3%, +14%, -4...Continue Reading

References

Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H LyngE K Rofstad
Apr 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wyndham H WilsonJohn E Janik
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian FurthPatrick Hundsdoerfer
Dec 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michal Weiler-SagieOra Israel
Dec 24, 2009·AJR. American Journal of Roentgenology·Carmel G CroninJohn F Bruzzi
Jan 20, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fabio M PaesAldo N Serafini
Apr 27, 2011·Blood·René-Olivier CasasnovasUNKNOWN Groupe d'étude des lymphomes de l'adulte (GELA)
Oct 2, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Chieh LinAlain Rahmouni
Nov 24, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M GhielminiUNKNOWN Panel Members of the 1st ESMO Consensus Conference on Malignant Lymphoma
Mar 8, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Katja De PaepeVincent Vandecaveye
Apr 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S LuminariM Federico
Feb 13, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Lale Kostakoglu, Bruce D Cheson
Feb 27, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Michel MeignanAnnibale Versari
Mar 4, 2014·Acta Radiologica·Trond HagtvedtTrond Mogens Aaløkken
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Mar 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marius E MayerhoeferMarkus Raderer
Mar 31, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sarah Toledano-MassiahAlain Rahmouni
Apr 17, 2015·British Journal of Cancer·E PapaevangelouN M deSouza
Jan 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Heiko SchoderCraig Moskowitz
Feb 24, 2016·European Journal of Nuclear Medicine and Molecular Imaging·N George MikhaeelSally F Barrington
Mar 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne-Ségolène CottereauStéphanie Becker
Aug 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel MeignanJudith Trotman
Apr 16, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sally F Barrington, Regine Kluge
Jun 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Julien LazaroviciDavid Ghez

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Citations

Mar 29, 2019·Diagnostics·Natasha Hemicke LangerBarbara Malene Fischer
Jul 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Marius E MayerhoeferHeiko Schöder
Jul 6, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L Leon-MateosL Gorospe
Oct 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Roberto García-FigueirasJoan C Vilanova
Oct 25, 2020·International Journal of Clinical Oncology·Shintaro YamanakaYoshihiro Yakushijin
Jun 26, 2020·Cancer Immunology Research·Marius E MayerhoeferPhilipp B Staber

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Methods Mentioned

BETA
imaging technique
biopsy
pregnancy test
xenografts
biopsies

Software Mentioned

syngo Multimodality Workplace environment
syngo
SPSS Statistics

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