Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal-derived foods, soil, and water

Journal of Separation Science
Ying ZhangYongquan Zheng

Abstract

An ultra high-performance liquid chromatography with tandem triple quadrupole mass spectrometry residue method was developed and validated for the quantification and identification of dinotefuran and its main metabolites 1-methyl-3-(tetrahydro-3-furylmethyl) urea and 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine in fruit (watermelon), vegetable (cucumber), cereal (rice), animal-derived foods (milk, egg, and pork), soil, and water. The samples were extracted with acetonitrile containing 15% v/v acetic acid and purified with dispersive solid-phase extraction with octadecylsilane, primary secondary amine, graphitized carbon black, or zirconia-coated silica prior to analysis. The method had an excellent linearity (R2  ≥ 0.9942, 1-500 μg/L) and satisfactory recoveries (73-102%) at five spiked levels (0.001, 0.01, 0.05, 0.5, and 2 mg/kg) with intra- or interday precision in the range of 0.8-9.5% and 3.0-12.8% for the three compounds in the eight matrices. The limits of quantification were 10 μg/kg for 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1 μg/kg for 1-methyl-3-(tetrahydro-3-furylmethyl) urea and dinotefuran. The applicability of the developed method was demonstrated by determining the occurrence of dinotefuran, 1-met...Continue Reading

References

Nov 23, 2006·Chemical Research in Toxicology·Kevin A Ford, John E Casida
Jun 19, 2008·Pest Management Science·Alfred ElbertRalf Nauen
Oct 17, 2008·Journal of Agricultural and Food Chemistry·Kevin A Ford, John E Casida
May 16, 2012·Journal of Chromatographic Science·Virgínia C FernandesCristina Delerue-Matos
Apr 13, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Malgorzata Gbylik-SikorskaAndrzej Posyniak
Jul 23, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Maha F Abdel-GhanyMichael W Linscheid

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Citations

Aug 14, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Kai CuiYongquan Zheng
Apr 14, 2021·The Science of the Total Environment·Ying ZhouJunyu Guo

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