PMID: 9191524Jun 15, 1997Paper

Ultra-late recurrence (15 years or longer) of cutaneous melanoma

Cancer
H TsaoA J Sober

Abstract

Melanoma can remain clinically quiescent for decades before regional or distant recurrence appears. This protracted disease free interval challenges the concept of a "cure" for melanoma. To understand this prolonged dormancy better, the authors retrospectively studied patients who developed recurrent melanoma 15 years or longer after their initial diagnosis ("ultra-late" recurrence). These cases were identified from 2766 melanoma diagnoses available in the Cancer Registry at the Massachusetts General Hospital (MGH). Histologic features of the primary lesion were also included when possible. Twenty cases were retrieved from the MGH database. There were equal numbers of women and men, although women were younger at the time of initial diagnosis (mean age of women: 29.8 years vs. 43.0 years for men). No patients had more than one primary cutaneous melanoma. The trunk was the most common primary site (35%), although there was no predominant anatomic localization. The average disease free interval was 17.3 years for women, 20.0 years for men, 18.1 years for patients with regional recurrence, and 19.0 years for patients with distant metastases. Distant recurrence was the most common type of recurrence (50% of women and 60% of men). T...Continue Reading

Citations

Oct 13, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Zafer OzsoyMine G Gulluoglu
Nov 22, 2008·World Journal of Surgical Oncology·Anastasios BoutisCharalambos Andreadis
Nov 28, 2001·Clinical and Experimental Dermatology·L A FearfieldC B Bunker
Oct 27, 2001·International Journal of Dermatology·C S JohnsonA M Hassanein
Feb 18, 2014·Critical Reviews in Oncology/hematology·Stefan RodicRamy R Saleh
Mar 11, 2004·The Journal of Investigative Dermatology·David A BarzilaiGregory S Cooper
Jan 18, 2006·The Journal of Investigative Dermatology·Henrik SchmidtHans von der Maase
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Feb 24, 2006·Journal of Surgical Oncology·Dan D HershkoJeffrey J Sussman
Sep 7, 2002·Cancer·John W GamelHilliard F Seigler

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