Ultra-Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS)-Based Pharmacokinetics and Tissue Distribution Study of Koumine and the Detoxification Mechanism of Glycyrrhiza uralensis Fisch on Gelsemium elegans Benth

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Lin WangFan-Hao Meng

Abstract

Gelsemium elegans Benth. (G. elegans), which is a famous Chinese folk medicine, has been commonly used to treat certain types of skin ulcers and alleviate inflammation, headaches, and cancer pain. However, the extensive clinical use of G. elegans has been greatly hampered by its toxicity. As one of the most widely used herbal medicines, Glycyrrhiza uralensis Fisch, has a unique effect on detoxification of G. elegans. In the present study, a rapid and sensitive method using ultra-liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was established and validated for determination of koumine, the most abundant molecule among the alkaloids of G. elegans, in rat plasma, tissue, and liver microsome. The developed method was successfully applied to the pharmacokinetics, tissue distribution, and in vitro metabolism study in rat with or without pre-treated Glycyrrhiza uralensis Fisch extract. Meanwhile, the expression level of CYP3A1 mRNA was analyzed to explain the detoxification mechanism of Glycyrrhiza uralensis Fisch on G. elegans. As a result, our work demonstrated that Glycyrrhiza uralensis Fisch could significantly affect the pharmacokinetics and tissue distribution of koumine in rats. The detoxification mechanism of Glycy...Continue Reading

References

Oct 3, 2003·Journal of Ethnopharmacology·C RujjanawateA Panthong
Oct 9, 2014·Anaesthesiology Intensive Therapy·Zbigniew KarwackiMałgorzata Witkowska
Aug 9, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yanxian HuLing Ye
Oct 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Hang YuanZhi-Liang Sun

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Citations

Dec 11, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Yinuer HaPingping Gan
Aug 1, 2020·BioMed Research International·Xiuwei ShenMeiling Zhang
Jun 18, 2019·Current Drug Metabolism·Zi-Yuan WangZhao-Ying Liu
May 27, 2020·Rapid Communications in Mass Spectrometry : RCM·Zi-Yuan WangZhao-Ying Liu
Jan 9, 2021·The American Journal of Chinese Medicine·Jun-Yan XiangQiuhong Xie
Aug 26, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xue-Jia QiZhao-Ying Liu
Jan 13, 2022·Human & Experimental Toxicology·Yu-Juan LiZhi-Liang Sun

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Methods Mentioned

BETA
PCR

Software Mentioned

spss

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