Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons

Neuroscience Letters
Eugen BrailoiuNae J Dun

Abstract

The present study was undertaken to evaluate the effects of ultra low concentrations (10(-9) or 10(-14)M) of morphine on neurite elongation in cultured neurons dissociated from rat spinal cords and cerebral cortex. In fetal serum (FS) or fetal serum-free supplemented with cAMP media, the length of longest neurite was significantly increased by 10(-9) or 10(-14)M morphine. For example, 10(-14)M morphine increased neurite length by 24 +/- 0.5% and 27 +/- 0.3% in spinal cord neurons, and 18 +/- 0.2% and 17 +/- 0.6% in cortical neurons. Morphine (10(-6)M) had no significant effect on neurite length of spinal and cortical neurons. The relative frequency distribution of neurite length revealed 61 +/- 2.7% of spinal neurons and 48 +/- 2.6% of cortical neurons are responsive to ultra low concentrations of morphine. In the responsive populations, morphine (10(-14)M) enhanced the neurite outgrowth in spinal neurons by 58 +/- 0.9% and 48 +/- 1.2% and in cortical neurons by 31 +/- 0.6% and 28 +/- 0.9% in FS and cAMP-supplemented media, respectively. Pretreatment with naloxone did not prevent the morphine effect. The result shows that morphine at ultra low concentrations enhances neurite outgrowth of spinal and cortical neurons via a naloxo...Continue Reading

References

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Citations

Nov 10, 2010·Biogerontology·Tatyana A DubileyAlexander M Vaiserman
Aug 19, 2010·Molecular Pharmacology·Fatima Macho Sanchez-SimonRaquel E Rodriguez
Mar 11, 2008·PloS One·Arnaud MullerYannick Goumon
Jul 22, 2010·The European Journal of Neuroscience·Fatima Macho Sanchez-SimonRaquel E Rodriguez
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Nov 6, 2004·The Journal of Biological Chemistry·Eugen BrailoiuNae J Dun
May 16, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li QianPatrick M Flood

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