Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Nanoscale
Tze-Sian PuiPeng Chen

Abstract

Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.

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Citations

Mar 19, 2013·Biosensors & Bioelectronics·Bor-Ran LiYit-Tsong Chen
Mar 23, 2011·Analytical Chemistry·Yinxi HuangPeng Chen
Oct 24, 2012·Lab on a Chip·Yuri D IvanovAlexander I Archakov
Nov 1, 2012·Sensors·Yekbun Adiguzel, Haluk Kulah
May 3, 2014·Biosensors & Bioelectronics·Mo-Yuan ShenYaw-Kuen Li
Sep 10, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·K A MalsagovaD A Nasimov
Dec 7, 2011·Chemical Society Reviews·Yuxin LiuPeng Chen
Jan 28, 2015·Analytica Chimica Acta·Jingquan LiuWenrong Yang
May 16, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·T O PleshakovaA I Archakov
Nov 13, 2010·Molecular and Cellular Endocrinology·Aung ThanPeng Chen

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