Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy

NMR in Biomedicine
Timo LiimatainenOlli H J Gröhn

Abstract

We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.

References

Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A van den BoogaartJ R Griffiths
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TkácR Gruetter
Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter, I Tkác
Aug 1, 2000·Trends in Biochemical Sciences·J M Hakumäki, R A Kauppinen
Dec 13, 2001·Journal of Magnetic Resonance·M Garwood, L DelaBarre
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shalom MichaeliWei Chen
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter VermathenChris Boesch
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bassem HibaAnne Ziegler
Oct 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arto ImmonenSeppo Ylä-Herttuala
Jan 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D RobsonStefan Neubauer

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Citations

Jul 25, 2007·AJR. American Journal of Roentgenology·Stephen J KarlikRethy Chhem
Sep 14, 2007·Journal of Magnetic Resonance·Julien ValettePierre-Gilles Henry
May 4, 2011·NMR in Biomedicine·E James DelikatnyHarish Poptani
Jul 1, 2015·Analytical and Bioanalytical Chemistry·M Carmen Martínez-BisbalVicent Esteve
Sep 23, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vladimír MlynárikRolf Gruetter
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vladimír MlynárikRolf Gruetter
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adrian R Parry-JonesNancy J Rothwell
May 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timo J LiimatainenJuhana M Hakumäki
May 21, 2019·NMR in Biomedicine·Sean Philip ArlauckasEdward James Delikatny

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