Ultra wide field fluorescein angiography can detect macular pathology in central retinal vein occlusion

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Irena TsuiSteven D Schwartz

Abstract

The purpose of this study was to evaluate whether ultra wide field fluorescein angiography (UWFFA), a tool established for the detection of peripheral non-perfusion, can also detect macular pathology. A retrospective imaging review was performed on patients with central retinal vein occlusion. UWFFA was graded for angiographic leakage (petalloid and/or diffuse leakage) and presence of abnormalities in the foveal avascular zone and was then correlated to spectral-domain optical coherence tomography (SD-OCT). Sixty-six eyes met inclusion criteria. Intergrader agreement was highly reliable for grading macular leakage on UWFFA (kappa = 0.75) and moderately reliable for the evaluation of an abnormal foveal avascular zone (kappa = 0.43). Angiographic leakage on UWFFA correlated to macular edema on SD-OCT (P > .0001), and abnormalities in the foveal avascular zone on UWFFA correlated to ganglion cell layer atrophy on SD-OCT (P = .0002). Intergrader reliability in grading UWFFA was better when assessing macular leakage than when assessing macular ischemia. UWFFA findings correlated to macular edema and signs of macular ischemia on SD-OCT.

References

Aug 23, 2008·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Thomas R FribergSteven D Schwartz
Feb 26, 2009·Seminars in Ophthalmology·Andrew KainesSteven Schwartz
May 12, 2009·American Journal of Ophthalmology·Sandeep GroverKakarla V Chalam
Feb 5, 2010·Investigative Ophthalmology & Visual Science·Yalin ZhengSimon P Harding
Nov 26, 2010·Retina·Irena TsuiSteven D Schwartz

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Citations

Jan 7, 2014·Oman Journal of Ophthalmology·Marcus Kernt, Anselm Kampik
Jun 6, 2015·International Ophthalmology·Asima BajwaAshvini K Reddy
Jul 27, 2014·American Journal of Ophthalmology·Shuntaro OguraYuichiro Ogura
Dec 19, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Mehreen AdhiRishi P Singh
Mar 13, 2014·Current Opinion in Ophthalmology·Mrinali Patel, Szilard Kiss
Feb 6, 2020·Therapeutic Advances in Ophthalmology·Samir N PatelMichael A Klufas
Jan 1, 2020·International Journal of Retina and Vitreous·Marguerite O Linz, Adrienne W Scott

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