Ultracentral Tumors Treated With Stereotactic Body Radiotherapy: Single-Institution Experience

Clinical Lung Cancer
Srinivas RamanMeredith E Giuliani

Abstract

Patients with ultracentral lung tumors, whose planning target volume directly contacts or overlaps the proximal bronchial tree, trachea, esophagus, pulmonary vein, or pulmonary artery, may be at higher risk of toxicity when treated with stereotactic body radiotherapy (SBRT). We reviewed the outcomes and toxicities of ultracentral lung tumors and compared the results with central lung tumors. A review of our institutional prospective database of patients treated with lung SBRT from January 2006 to December 2015 was conducted. Patients with central tumors (RTOG 0813 definition) and ultracentral tumors were included. In total, 180 central and 26 ultracentral tumors were analyzed. The majority of patients received 60 Gy in 8 fractions (53.9%) or 48 Gy in 4 fractions (29.1%). The rates of any grade 2 or higher toxicity were 8.4% (n = 16) in the central group and 7.9% (n = 2) in the ultracentral group (P = .88). There were no observed grade 4 or 5 toxicities. In the nonmetastatic primary lung cancer cohort (n = 182), the median overall survival was 39.4 months versus 23.8 months (P = .40) and cause-specific survival was 55.5 months versus 28.2 months (P = .34) for central and ultracentral tumors, respectively. The 2-year cumulative l...Continue Reading

Citations

Sep 25, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mauro LoiMarta Scorsetti
Jan 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M DuijmJ Nuyttens
Mar 13, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·William G BreenDawn Owen
Apr 7, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Karin LindbergRolf Lewensohn
Apr 27, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Neal AndruskaUNKNOWN Advanced Radiation Therapy Committee for the International Association for the Study of Lung Cancer
Jun 27, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Hatim FakirJoanna Laba
Jul 1, 2021·Acta Oncologica·Joyce E LodewegesJoost J C Verhoeff
Sep 28, 2021·International Journal of Radiation Oncology, Biology, Physics·Arya AminiJoe Y Chang
Apr 9, 2019·International Journal of Radiation Oncology, Biology, Physics·David PalmaMeredith Giuliani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.