Ultradian pulsatility of plasma glucose and insulin secretion rate: circadian and sleep modulation

Hormone Research
C Simon

Abstract

Insulin release is a complex oscillatory process with rapid pulses (10 min) superimposed on slower circhoral oscillations (50-100 min). The exact mechanism of the circhoral oscillations, which are probably in part the consequence of a negative feedback loop linking glucose and insulin secretion rate, remains unclear. Stimulatory effects of sleep on insulin secretion are achieved by an enhancement of the oscillation amplitude which could be partly mediated by GH. The different patterns observed after acute or chronic shift of sleep suggest however an interaction between sleep influence and circadian rhythmicity, as described for numerous pituitary hormones. The intra-sleep awakenings have a modulatory effect on glucose levels but no systematic relationship exists between glucose or insulin secretion rate oscillations and the REM-NREM sleep cycles. Irrespective of the mechanisms involved, sleep or GH stimulatory effects result from a modulation of the oscillation amplitude rather than of their frequency which is probably an important feature of insulin efficacy.

Citations

Apr 28, 2004·Journal of Biomaterials Science. Polymer Edition·Nicholas A Peppas, William Leobandung
Feb 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Steven A SheaChristos S Mantzoros
Jun 3, 2008·Sleep Medicine Clinics·Kristen L Knutson
Apr 21, 2010·IEEE Transactions on Bio-medical Engineering·Yinghui LuJaques Reifman
Aug 31, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J C Levy
Feb 3, 2000·Critical Reviews in Clinical Laboratory Sciences·J Himms-Hagen

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