Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress

Endocrinology
R J WindleC D Ingram

Abstract

The present study investigated the dynamic regulation of the hypothalamo-pituitary-adrenal axis and its significance to acute stress responsiveness in the female rat. An automated, frequent blood-sampling technique allowed the circadian rhythm of corticosterone to be resolved into a series of pulses. These were equally distributed (mean interval, 50.9 +/- 3.7 min) throughout the 24-h cycle, but their magnitude varied significantly, being higher between 1800-2200 h (137 +/- 9 ng/ml) than between 0600-1000 h (75 +/- 17 ng/ml). This pattern of release indicates continuous, but variable, activity of the axis throughout the day. The pulsatile ultradian rhythm suggested alternate periods of secretion and inhibition, which were found to have a profound effect on the corticosterone responses to acute stress. Noise stress (10 min, 114 decibels) evoked a transient increase in corticosterone, which reached a maximum (377 +/- 87 ng/ml) 20 min after onset. However, within this group (n = 26) the response varied depending on the underlying basal activity. When stress coincided with a rising (secretory) phase of a pulse, corticosterone concentrations rose to 602 +/- 150% of mean basal concentrations (P < 0.001). In contrast, when stress coinc...Continue Reading

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Citations

Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·N ShanksS L Lightman
Feb 5, 2010·Proceedings. Biological Sciences·Jamie J WalkerStafford L Lightman
Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M KeenanJohannes D Veldhuis
Feb 10, 2011·Endocrinology·Francesca SpigaStafford L Lightman
Apr 6, 2011·Wiener klinische Wochenschrift·Bastian OpplReinhard Kofler
Jun 1, 2010·European Journal of Applied Physiology·C Martyn BeavenWill G Hopkins
Apr 11, 2015·International Journal of Endocrinology·Tae Won KimSeung-Chul Hong
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Dec 22, 2004·The Journal of Physiology·J V SealeS L Lightman
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Signe F BomholtRuth E Blackburn-Munro
Jan 17, 2017·Physiology & Behavior·James P Herman, Kellie L Tamashiro
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