Ultraestructural study of effects of alkylphospholipid analogs against nematodes

Experimental Parasitology
Viviane Sant'annaWanderley de Souza

Abstract

Alkylphospholipid analogs were initially developed as anticancer agents and were later found to antiparasitic activity. Miltefosine is the prototype alkylphosphocholine and is the first oral treatment against visceral leishmaniasis. Here we investigated the effects of miltefosine and two ring-substituted alkylphosphocholine derivatives, TCAN26 and TC70, on the viability, morphology, and ultrastructure of the life stages of Caenorhabditis elegans and infective larvae of the parasite Strongyloides venezuelensis. Miltefosine displayed activity against C. elegans adults at low concentrations and was more effective than TCAN26 and TC70. Miltefosine inhibited the hatching of eggs, leading to embryonic lethality, and showed larvicidal activity against C. elegans and S. venezuelensis larvae after 24 h. Mitelfosine also induced alterations in the reproductive system of hermaphrodites, causing vulvar prolapse and general effects in the body wall. Electron microscopy analysis showed that miltefosine induced selective embryonic lethality, leading to cell death. Our results suggest that alkylphospholipid analogs are a potential new alternative for anti-nematode chemotherapy.

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Citations

Mar 14, 2020·Medicinal Research Reviews·Daniel Sepúlveda-CrespoMaría Martínez-Valladares
Jul 26, 2019·Current Topics in Medicinal Chemistry·Jéssica Peixoto RodriguesLuiz Ricardo Goulart
Nov 8, 2020·BMC Complementary Medicine and Therapies·Pawi Bawitlung Lalthanpuii, Kholhring Lalchhandama
Oct 20, 2018·Biochimica Et Biophysica Acta. Biomembranes·Karla PetitKazimierz Strzalka

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