Ultrafast Hypothermia Selectively Mitigates the Early Humoral Response After Cardiac Arrest.

Journal of the American Heart Association
Emilie BoissadyRenaud Tissier

Abstract

Background Total liquid ventilation (TLV) has been shown to prevent neurological damage though ultrafast cooling in animal models of cardiac arrest. We investigated whether its neuroprotective effect could be explained by mitigation of early inflammatory events. Methods and Results Rabbits were submitted to 10 minutes of ventricular fibrillation. After resuscitation, they underwent normothermic follow-up (control) or ultrafast cooling by TLV and hypothermia maintenance for 3 hours (TLV). Immune response, survival, and neurological dysfunction were assessed for 3 days. TLV improved neurological recovery and reduced cerebral lesions and leukocyte infiltration as compared with control (eg, neurological dysfunction score=34±6 versus 66±6% at day 1, respectively). TLV also significantly reduced interleukin-6 blood levels during the hypothermic episode (298±303 versus 991±471 pg/mL in TLV versus control at 3 hours after resuscitation, respectively), but not after rewarming (752±563 versus 741±219 pg/mL in TLV versus control at 6 hours after resuscitation, respectively). In vitro assays confirmed the high temperature sensitivity of interleukin-6 secretion. Conversely, TLV did not modify circulating high-mobility group box 1 levels or ...Continue Reading

Associated Clinical Trials

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Quentin de RouxRenaud Tissier
Aug 3, 2021·Experimental and Therapeutic Medicine·Shuangshuang LuJin Huang

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Methods Mentioned

BETA
flow cytometry

Clinical Trials Mentioned

NCT00999583

Software Mentioned

GraphPad
Prism
Fluorojade

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