Ultrafast Killing and Self-Gelling Antimicrobial Imidazolium Oligomers

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Siti Nurhanna RiduanYugen Zhang

Abstract

Infectious diseases and the increasing threat of worldwide pandemics have underscored the importance of antibiotics and hygiene. Intensive efforts have been devoted to developing new antibiotics to meet the rapidly growing demand. In particular, advancing the knowledge of the structure-property-activity relationship is critical to expedite the design and development of novel antimicrobial with the needed potential and efficacy. Herein, a series of new antimicrobial imidazolium oligomers are developed with the rational manipulation of terminal group's hydrophobicity. These materials exhibit superior activity, excellent selectivity, ultrafast killing (>99.7% killing within 30 s), and desirable self-gelling properties. Molecular dynamic simulations reveal the delicate effect of structural changes on the translocation motion across the microbial cell membrane. The energy barrier of the translocation process analyzed by free energy calculations provides clear kinetic information to suggest that the spontaneous penetration requires a very short timescale of seconds to minutes for the new imidazolium oligomers.

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Citations

Sep 16, 2017·Chemistry : a European Journal·Carla RizzoFrancesca D'Anna
Jul 25, 2019·Critical Reviews in Biotechnology·Guangshun YiYugen Zhang
Dec 16, 2020·ACS Biomaterials Science & Engineering·Yuan YuanYugen Zhang

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