Ultrafast Photogeneration of a Tetrazolinyl Radical

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Florian KanalPatrick Nuernberger

Abstract

Radicals in solution are crucial for many chemical processes. In this work, we unveil the photoreaction sequence leading to radical formation from tetrazolium salts, which are extensively used in enzyme assays and also exhibit a rich photochemistry. Upon UV irradiation, the tetrazolium ion turns into the tetrazolinyl radical via two intermediates on a nanosecond timescale. The solvent's polarity governs the rate of formation, but the reaction pathway towards the tetrazolinyl radical is identical for aqueous and alcoholic solutions, although the final photoproduct distribution differs. These observations provide new insight into the versatile reactivity of tetrazolium salts and ultrafast radical formation in the liquid phase.

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Citations

Oct 14, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Tom BolzePatrick Nuernberger
Nov 30, 2021·The Journal of Organic Chemistry·Svenja WortmannPatrick Nuernberger

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