Ultrafast sonochemical synthesis of protein-inorganic nanoflowers

International Journal of Nanomedicine
Bhagwan S BatuleHyun Gyu Park

Abstract

We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein and copper phosphate within 5 minutes at room temperature. The resulting laccase nanoflowers yielded greatly enhanced activity, stability, and reusability, and their usefulness was successfully demonstrated by applying them in the colorimetric detection of epinephrine. The strategy developed could be used to rapidly synthesize nanoflowers for various applications in biosensor and enzyme catalysis and would expand the utilization of nanoflowers in diverse fields of biotechnology.

Citations

Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu ZhouShangyong Li
Mar 12, 2021·Critical Reviews in Analytical Chemistry·Indra Gandi SubramaniNorani Muti Mohamed
Jan 31, 2018·Journal of Agricultural and Food Chemistry·Bhagwan S BatuleMin-Gon Kim

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Methods Mentioned

BETA
biosensors
Scanning electron microscopy
X-ray
protein assay
biosensing
biosensor

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