Ultrafast vibrational dynamics of the DNA backbone at different hydration levels mapped by two-dimensional infrared spectroscopy

Structural Dynamics
Biswajit GuchhaitThomas Elsaesser

Abstract

DNA oligomers are studied at 0% and 92% relative humidity, corresponding to N < 2 and N > 20 water molecules per base pair. Two-dimensional (2D) infrared spectroscopy of DNA backbone modes between 920 and 1120 cm(-1) maps fluctuating interactions at the DNA surface. At both hydration levels, a frequency fluctuation correlation function with a 300 fs decay and a slow decay beyond 10 ps is derived from the 2D lineshapes. The fast component reflects motions of DNA helix, counterions, and water shell. Its higher amplitude at high hydration level reveals a significant contribution of water to the fluctuating forces. The slow component reflects disorder-induced inhomogeneous broadening.

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Citations

Apr 16, 2016·The Journal of Physical Chemistry. B·Gordon HithellNeil T Hunt
Jul 29, 2016·The Journal of Physical Chemistry Letters·Torsten SiebertThomas Elsaesser
Jan 7, 2017·Chemical Reviews·Ayanjeet GhoshMartin T Zanni
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May 5, 2017·Structural Dynamics·Damien LaageJames T Hynes
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nassim BeiranvandElfi Kraka
Jul 10, 2021·The Journal of Chemical Physics·Christopher P BaryiamesCarlos R Baiz
Jul 9, 2021·The Journal of Physical Chemistry. B·Robert J FickAllison L Stelling
Aug 5, 2017·ACS Central Science·M Luke McDermottPoul B Petersen
Jul 10, 2019·The Journal of Physical Chemistry. B·Sheh-Yi SheuDah-Yen Yang
Feb 27, 2020·The Journal of Physical Chemistry. B·Achintya KunduThomas Elsaesser
Jan 18, 2018·The Journal of Physical Chemistry Letters·Eva M BrueningThomas Elsaesser

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Methods Mentioned

BETA
x-ray diffraction
infrared spectroscopy
circular

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